#lysosome

https://www.europesays.com/uk/30594/ Commander Gene Variants Contribute to Parkinson’s Disease Risk #Genetics #HumanGenome #lysosome #Parkinson'sDisease #Science #UK #UnitedKingdom

Focus sur la Maladie de #Parkinson :

2 mécanismes de progression distinctes = 2 dysfonctionnements cellulaires.
-> la #mitochondrie : structure cellulaire générant l'énergie nécessaire aux cellules = aspects moteurs.
-> le #lysosome : organite cellulaire effectuant la digestion intracellulaire = troubles cognitifs #cerveau

cf https://mastodon.social/@cobrate/114166007687595849

#science #sante

"Our study demonstrates a unique role for MANF in autophagy and lysosome function, critical processes for clearing toxic proteins. In the animal model Caenorhabditis elegans, overexpressing MANF extended lifespan, reduced protein clumps, and conferred protection on neurons. These roles of MANF are mediated by the HLH-30/TFEB, a master regulator of lysosome function"

https://www.pnas.org/doi/10.1073/pnas.2403906121

#autophagy #neuron #aging #lysosome #biology

Scientists identify novel #lysosome #fission factor.

#HEAT #HPO_27

https://phys.org/news/2024-03-scientists-lysosome-fission-factor.html

Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of #lysosome function.

@maxgabgut &co propose a 'lysosome states' concept that links single lysosomes to function.

#PLOSBiology #cellbiology

https://plos.io/3xatAMA

Il y a 18 ans, Maëlyn est née et je suis devenue tante 🫶 Depuis, elle vit différement que la plupart de nous, avec une qualité de vie bien inférieure à ce que nous avions imaginé en 2005.

Ses parents sont devenus proches aidants.

J'ai recalibré ma vie professionnelle pour travailler sur des maladies rares.

Et toi, pourrais-tu envoyer quelques sous à l'association Vaincre les Maladies Lysosomales qui nous aide tant?

https://www.gandee.com/participate/1494

#batten
#rare
#lysosome

Failure of #ProteinQC in #Celegans triggers a mechanism involving pathogen response factors & #lysosome-mediated degradation, promoting tissue-specific resilience to age-dependent #ProteinAggregation & #proteotoxicity @DellaDavid_Lab &co #PLOSBiology https://plos.io/44QeDdD

'Here, we analyzed #lysosome subcellular distribution in micropatterned patient-derived melanoma cells and found that lysosome spreading scales with their aggressiveness.'
#Preprint #Melanoma

https://www.biorxiv.org/content/10.1101/2023.07.07.548108v1

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn

Are you ready for your reading list for the week?

Check out this week's edition of publications on #MembraneContactSites!

http://biomed.news/bims-mecosi/2023-01-29

Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!

#MAMs #MCS #Mitochondria #Lysosome #Proteostasis

Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosome

#preprint #biorxiv #lysosome

https://www.biorxiv.org/content/10.1101/2022.11.23.517579v1