#mTORC1

mTORC1 Research: New Findings Challenge Old Model Congrats to the Demetriades Lab team! #mTORC1
#Research

https://www.age.mpg.de/415628/241122_mtor_on_the_move?c=2930

An exciting article out in @biorxivpreprint shows that AMPK inhibits autophagy during glucose starvation in U2OS cells.

https://www.biorxiv.org/content/10.1101/2023.09.28.559981v2

Whether glucose starvation induces or inhibits autophagy is a controversial topic, something my lab discovered when we struggled for almost two years to publish our findings that in yeast glucose starvation actually actively suppresses autophagy ten years ago.

https://pubmed.ncbi.nlm.nih.gov/24753258/

#autophagy #AMPK #mTORC1 #CellBiology

Interesting . A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.

A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1

https://doi.org/10.1126/science.abj5559