#mitophagy

Fully Funded PhD Position in Cancer Research

Hebrew University of Jerusalem

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606

#autophagy #cancer_biology #cell_death #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

Research uncovers specific #protein interactions needed for #cells to break down and remove damaged #mitochondria.

#autophagy #TBK1 #mitophagy

https://phys.org/news/2024-03-uncovers-specific-protein-interactions-cells.html

The ER membrane protein complex restricts #mitophagy by controlling BNIP3 turnover
Jose Delgado, Samantha Liu, Christopher Shoemaker et al
https://www.embopress.org/doi/full/10.1038/s44318-023-00006-z

• Hormones #metabolism is intricately linked to #mitochondrial quality-control.
• #Hormones regulate both mitochondria & #mitophagy.
• Dysregulated mitophagy contribute to development of #endocrine disorders.
• Targeting mitophagy is an innovative approach for treating ED.
https://www.sciencedirect.com/science/article/pii/S0753332223012660

PhD studentships

Hebrew University of Jerusalem

Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983

#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=58983

PhD studentships

Hebrew University of Jerusalem

Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172

#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55172

PhD studentships

Hebrew University of Jerusalem

Come join us in Rehovot for an exciting PhD project, in which we will try and understand the ways in which cells their mitochondria for degradation.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165

#ScienceJobs #hiring #research #mitophagy
Rehovot #Israel #PhD...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-phd-studentships-2/?feed_id=55165

Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1

Debasna Panigrahi, Sujit Bhutia identify MTP18 as a novel #mitophagy receptor and discover that MTP18-dependent mitophagy has implications in oral #cancer progression.
https://journals.biologists.com/jcs/article/136/13/jcs259986/323419/The-inner-mitochondrial-membrane-fission-protein

You can read more about this research in our ‘First person’ interview with Debasna Panigrahi: https://journals.biologists.com/jcs/article/136/13/jcs261435/323418/First-person-Debasna-Panigrahi

#cellbiology #cancerbiology #mitochondria

Exploitation of host cell #organelles by an intracellular #pathogen: #Brucella abortus not only uses the ER to replicate, but later also localizes to and fragments #mitochondria to aid bacterial egress via #mitophagy
Thierry Arnould et al
https://www.embopress.org/doi/10.15252/embj.2022112817

How are specific dysfunctional #mitochondria removed under steady-state conditions?

Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

https://www.embopress.org/doi/10.15252/embj.2022112767

What controls basal, #Parkin-independent #mitophagy?

E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

https://www.embopress.org/doi/10.15252/embj.2022112799

Interesting new paper from Orian Shirihai's group in @embojournal
"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
https://www.embopress.org/doi/full/10.15252/embj.2022111699

Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast

#mitochondria #mitophagy #metabolism

https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/

How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

https://www.embopress.org/doi/10.15252/embj.2022113033

Enhancing #mitophagy promote survival of dopaminergic neurons; @NataliaMoskal3 &co show that effects of Probucol on lipid droplet expansion can augment mitophagy in neurons, improving locomotion in zebrafish & fly models of #ParkinsonsDisease #PLOSBiology https://plos.io/3IJQM6n