#morphogens
These are public posts tagged with #morphogens. You can interact with them if you have an account anywhere in the fediverse.
How do morphogen signals instruct stem cells to acquire a specific neuronal identity? A #preprint by Neal Amin, Kevin Kelley and team provides us with a roadmap. 
Great new #preLight from Monica Tambalo which includes a response from the authors...
#preLight 
https://prelights.biologists.com/highlights/generating-human-neural-diversity-with-a-multiplexed-morphogen-screen-in-organoids/
@persagen@mastodon.socialEmergent digital bio-computation through spatial diffusion & engineered bacteria
https://www.biorxiv.org/content/10.1101/2023.07.07.548081v1?rss=1
Our computers are composed of bacterial colonies which receive information in the form of diffusible morphogen-like signals.
A computation is encoded by the physical locations of the input morphogen & the output receiver colonies.
These computational bacterial communities will help explore information processing in biological systems.
Building computationally capable biological systems…
www.biorxiv.orgCombinatorial interpretation of BMP and WNT allows BMP to act as a morphogen in time but not in concentration.
"[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
https://www.biorxiv.org/content/10.1101/2022.11.11.516212v1?rss=1
#DevBio #CellFate #GermLayers #morphogens #Differentiation