#purine

Scientists uncover a multibillion-year epic written into the #chemistry_of_life.

#purine #biosynthesis #KEGG #evolution #ATP

https://phys.org/news/2024-05-scientists-uncover-multibillion-year-epic.html

"We find that #purine synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents. Early phases of the expansion are enriched with #enzymes that are metal dependent and structurally symmetric, supporting models of early #biochemical #evolution. This expansion trajectory suggests distinct hypotheses regarding the tempo, mode and timing of metabolic pathway evolution"

https://www.nature.com/articles/s41559-024-02361-4

LEARN FROM MY MISTAKES

https://purposeconsultant.wordpress.com/2013/02/01/can-too-much-nutritional-yeast-cause-gout/
#yeast #gout #purine

Happy to share our just accepted #review on #multitarget approaches for the #synthesis of #purine and #pyrimidine derivatives. From the #prebiotic/#abiotic origin of life to new #green #chemistry strategies for #drugdiscovery.
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ejoc.202201288?utm_source=google&utm_medium=paidsearch&utm_campaign=R3MR425&utm_content=Chemistry