Oncologists report “patients with rapidly progressing cancers of several types, such as breast cancer and renal cell carcinoma. 'The trend is getting more and more alarming. We are noticing trends in hematological malignancies, breast cancer, colorectal carcinoma, and pancreatic cancer.' Patel now fears a “perfect storm” of factors will trigger inflammatory responses, causing cancer to arrive years earlier than normal and making it deadlier once it is diagnosed.” #COVID19 https://www.ajmc.com/view/kashyap-patel-md-sees-link-between-covid-19-and-cancer-progression-calls-for-more-biomarker-testing
"CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer."
https://pubmed.ncbi.nlm.nih.gov/30520029/
"A dysfunctional state of the T cell arises when the host is challenged with a persistent viral infection, which is known as T cell exhaustion."
https://www.liebertpub.com/doi/10.1089/vim.2022.0002
"Notably, T-cells are dysregulated in severe COVID-19 patients...
...
"Severe COVID-19 patients show the reduction of all lymphocyte subsets including CD4+ and CD8+ T-cells, NK cells, and B cells..."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648511/
From before the pandemic, even.
"CD8 T-cell exhaustion has been argued to be an evolutionary adaptation to prevent immunopathology. To test this argument, we repeated our calculations in the absence of exhaustion. In contrast to the maximum seen above, we found that pathology now monotonically increased with viral inoculum and effector pool sizes, demonstrating that exhaustion curtails pathology associated with high viremia and enables host survival. The price, however, is viral persistence."
https://www.pnas.org/doi/abs/10.1073/pnas.1902178116
"From what is discussed above, it can be concluded that the infiltration and activity of CD8+ T cells can be used as a biomarker of response in cancer patients with SARS-CoV-2-induced diseases, and their dysfunctionality is a dominant reason for a more severe condition. Persistent infection and sustained stimulation are factors associated with the exhaustive state in CD8+ T cells."
https://www.frontiersin.org/articles/10.3389/fimmu.2022.864298/full
People have been warning us for 3 years that cancers would *eventually* become more frequent when T cells couldn't destroy early stage cancer cells as effectively anymore, and that the progression and mortality of cancers would go up. They said this would take years to be evident. That's been met with "Well they haven't yet!" by all sorts of minimizers.
@BE @augieray
I mean, just the fact that this could be a mere POSSIBILITY, is an outcome so dramatic that any SANE person would decide, it is worth taking countermeasures NOW to prevent this from happening. Worst case scenario, it wasn't necessary. Now though? But i am preaching to the choir here i guess, our leaders (and most people) really couldn't care less if they tried. Unless it hits THEM directly, they prefer to look the other way.