CIDRAP: "Contaminated meat likely source of avian flu that killed bush dogs in UK zoo, preprint suggests"

'Likely' is an interesting choice. Let's take a look at the alternative transmission possibilities noted in the study:

* scavenging of wild bird carcases/sick wild birds landing in the un-netted pen
* indirect contact (e.g., wild bird faeces)

Both of these possibilities can involve bioaerosols

"Wild bird activity was observed on the site during epidemiological investigations"

(Cont.) 🧵

The study's basis for suggesting that it was foodborne includes the speed of onset, but that isn't necessarily an airtight conclusion. Notably, the airways of the dogs were infected, which means airborne transmission was entirely possible. Dogs are also, like many animals, messy eaters, and it is possible that infected particles from scavenged birds -- like fecal aerosols -- were inhaled during the process of consumption

The reason this is important to point out is because H5N1 would require some significant mutations to become foodborne (and thus survive gastric acid), while its capability as an airborne pathogen is already thoroughly demonstrated across animal species

@currentbias

I suspect you know more about this than I do, so can you explain this gastric acid idea to me? When you inhale IRPs of, say, COVID, they replicate in your nasopharynx, your mouth, your throat, etc.

Why if you ate viral infected food would it not replicate "above" the stomach and any acid?

@BE

I am flattered you think so, but I am far from an expert on this -- just looking for blindspots in the epidemiology. I'm thinking of a hypothetical situation in which fecal aerosols in the intestine of a corpse are released and inhaled as the corpse is being consumed. I am not sure how possible inhaling particles trapped in something like muscle tissue would be. I'm moreover skeptical that gastric acid isn't simply annihilating the flu in these tissues as it's being consumed

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@currentbias

It's way out of my wheelhouse, too. I'm just wondering if chewing on an H5N1 infected steak would colonize your mouth and esophagus long before it got to your stomach acid.

But a quick search on this for bacteria didn't lead me to any conclusions, and I don't have enough time to figure it out properly at the moment 😂

@BE

Embarrassingly (for how hard I've been going on about this), that is an angle I hadn't considered, but it does seem quite plausible. Someone pointed out the outbreak among indoor cats in South Korea in 2023, which was linked to raw commercial cat food

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