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Always cool to see such modalities work out in vivo!
From @JunoThera -
Activation-inducible CAR expression enables precise control over engineered CAR T cell function https://www.biorxiv.org/content/10.1101/2022.11.08.515608v1
design: 'CAR construct integrated downstream of a T cell activation-dependent promoter'
Also from earlier this week based on similar tx design for epilespy,
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RT @akankshay58
Not at all an expert, but a fascinating data point that makes a case for 🧬 therapy because it's neat and it works!
'a strategy that self-selects neurons that are pathologically overactive and down-regulates their excitability in a closed loop'
🔴⏫activity->IEG-K+ channel->🟢📉 https://twitter.com/LignaniLab_UCL/status/1588231473072459781
https://twitter.com/akankshay58/status/1588295055688708097