Question for #HippocampalReplay people:

Can you think of any experiments where awake replay is observed outside of a goal / reward location?

(Specifically interested in replay i.e. sharp-wave / ripple - related #Reactivations, not theta sequences)

#Hippocampus #SWR

@elduvelle_neuro I'm recording from awake head-fixed mouse while they're exploring N=3 VR environments presented in an interleaved order. I see awake replay at the lap start (potentially another salient/surprise location especially in head-fixed VR with random environment order). Although, more replay events are near reward sites.

@rajatsaxena Interesting! Is the lap “start” just after being teleported from a rewarded “location”?

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@elduvelle_neuro Very Good point! In two environments, I do have a reward site within 50cm of teleportation (lap start), whereas in the other environment, it is further (125cm) away.. let me compare the replay in two environments and get back to you.

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