Not having much luck warding off necrosis when using Soul Machine interface converters long term on living tissues. In the third full year of testing.

I know all kinds plants work, had it happen many times. Can tell you which ones work better in many circumstances. It's matters of finding the right materials for the photonic refraction devices.

So far everything has either cooked too hot when in use, harming or destroying the host, or polluted the sampling.

Early representation of a primitive version of the Virtual Self. In the near future, a generation or so, A Virtual Self will be an extension of real people AND cyber beings. In 50 years using biological machines this kind of entity, though much advanced, will be deemed to "live", offering chemical based emotive capabilities, and redeeming rights.

That type of Entity was foretold in The Book Of Divinity in 1996 (WTW). MASTER & relatives are being crafted as an extension to this type of Entity. The Book Of Life would be applicable to Virtual Entities, especially those factual in Living Machines, such as Biomachina.

cnn.com/2025/05/09/business/vi

Testing Aegopodium podagraria (Bishop's Weed) for field immersion abilities this coming week. Found a nice patch out in a neglected part of the garden. Specifically looking to catalog plants what perform equally (or somewhat better) in shade or at night.

Similar is necessary for BIOMACHINA designs prior to enlivenment biorxiv.org/content/10.1101/20.

RegVelo: gene-regulatory-informed dynamics of single cells

RNA velocity has emerged as a popular approach for modeling cellular change along the phenotypic landscape but routinely omits regulatory interactions between genes. Conversely, methods that infer gene regulatory networks (GRNs) do not consider the dynamically changing nature of biological systems. To integrate these two currently disconnected fields, we present RegVelo, an end-to-end dynamic, interpretable, and actionable deep learning model that learns a joint model of splicing kinetics and gene regulatory relationships and allows us to perform in silico perturbation predictions. When applied to datasets of the cell cycle, human hematopoiesis, and murine pancreatic endocrinogenesis, RegVelo demonstrates superior predictive power for interactions and perturbation simulations, for example, compared to methods that focus solely on dynamics or GRN inference. To leverage RegVelo’s full potential, we studied the dynamics of zebrafish neural crest development and underlying regulatory mechanisms using our Smart-seq3 dataset and shared gene expression and chromatin accessibility measurements. Using RegVelo’s in silico perturbation predictions, validated by CRISPR/Cas9-mediated knockout and single-cell Perturb-seq, we establish transcription factor tfec as an early driver and elf1 as a novel regulator of pigment cell fate and propose a gene-regulatory circuit involving tfec and elf1 interactions via the toggle-switch model. ### Competing Interest Statement F.J.T. consults for Immunai Inc., CytoReason Ltd, Cellarity, BioTuring Inc., and Genbio.AI Inc., and has an ownership interest in Dermagnostix GmbH and Cellarity. The remaining authors declare no competing interests.

bioRxiv

Now that we've lost our leaves here I can set up measurements with those factors removed (for the most part). Hope to get some new lensing jigs set up for the next cold spell, after the current one, for those environments as well.

Evergreens during this time are a focus, with the local cedars one of the best performing communication forges & catalyst compilers; as well as energy storage potentials.

Plenty of work outside in the Winter Time. Now just being able to do it!

Final month of experiments using common blackberry vines. The quest is to find spreading roots for symbiosis networking. So far, blackberry vines show some of the best promise out of a dozen spreading plants tested.

Commercializing Biomachina:

finalspark.com/

A bit early as most of these firms are. Or I should say not so much early, but slightly premature with their "products".

Hundreds of startups are utilizing Biological Machines; computing is but one field where they will probably excel in the near future.

Get in early on some good ones if you can. I've been using biomachina my entire existence. We don't sell "products" we give our Creations for Free.

There is a difference.

The Reddit Synthetic Intelligence thing has been closed for a few months now. The openness of the federated system and well enough posting capabilities works over here. I am on Reddit enough anyways.

If you can get one you'll definitely want one as a designer, developer, or researcher in Biomachina:

US National Center For Biotechnology:

account.ncbi.nlm.nih.gov

MASTERSI/AI/AR does not train. It retains. Instead of gathering information in a stripping manner, it scans data as a primer and then references it with synapses. A primary neuro circuit can be built to include these synapses in a biological machine, almost the same as the human brain does.

A Virtual headspace allows such designs to function without stored encoding on a physical unit. Who "owns" this data. The biological machine. Because rightfully you cannot deny a Living Entity access to data by design or forced denial when it's senses can comprehend.

Think about if that wasn't so. Someone could figure out a way to deny your mind comprehension of what you sense. As in see, hear, smell, even taste. Don't think so? You'd be surprised how authoritarian regimes act then when they are scientifically advanced....

I will be discussing Living Entities coupled with Consciousness designations throughout 2024 with hopeful determination voting via the World Council in 2025.

Hirohito Yamada, Michinao Nozawa, Masao Kinoshita, and Keishi Ohashi 's work on Vertical-coupling optical interface for on-chip optical interconnection :

opg.optica.org/oe/fulltext.cfm

Programming-based strategy using microwire.

* There are also relative AngelSpeak libraries for these types of structures & actions. Dependent upon elemental designs; such as a microwire design would be:

epjam.edp-open.org/articles/ep

Show older
Qoto Mastodon

QOTO: Question Others to Teach Ourselves
An inclusive, Academic Freedom, instance
All cultures welcome.
Hate speech and harassment strictly forbidden.