Questions about the composition of future Covid vaccines.
#COVID #vaccines
https://www.medpagetoday.com/opinion/second-opinions/103017?s=09
This is all really interesting and I've been trying to wrap my head around the evolving science about imprinting and timing, in particular. Much of the science is not my background and I fear I'm slow on the uptake, but I'm trying.
If anyone's interested, here's some articles some of us have been kicking around over the last month or so that deal with the topic:
https://www.nature.com/articles/d41586-023-00086-1
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/102604
https://www.sciencedirect.com/science/article/pii/S1471490622000485
@BE @travelhealthdoc @noyes There are definitely questions not only as to the best composition of the mRNA vaccines but the most optimal timing. I'm actually hoping that, as valuable as the mRNA vaccines have been, we get better vaccines in the future with better mucosal immunity and far less waning effect.
IMO, given that:
The waning effect tit-for-tat dovetails with Short Term Germinal Center decay.
Introduction of nucleocapsid protein via Antibody Dependent Complement Mediated Lysis is responsible for the escalation from mild to Moderate/Severe Covid.
M-protein specific antibodies effect ADCML.
I suspect:
The protective effect of the current mRNA vaccines has more to do with an opportunity cost favoring anti-S over anti-M than neutralization or T affinity.
@BE Thank u for compiling them! 😊