Cows have human flu receptors, study shows, raising the stakes on the bird flu outbreak in dairy cattle | CNN

amp.cnn.com/cnn/2024/05/09/hea

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@shonin

I know in my H5N1 thread I have skewed towards more dense science and it's not exactly accessible to everyone. I've had a hard time finding time to summarize everything.

If I could synthesize this preprint, plus other papers I read into a short(er) talking point, it would be this:

"Human IAVs preferentially bind SA-α2,6 (human receptor)"

biorxiv.org/content/10.1101/20 (The paper cited in the CNN article)

"Ferrets are widely used as animal models for the study of influenza A infection because they have a similar distribution of SA α2,3-Gal and SA α2,6-Gal receptors in the respiratory tract as humans."

ncbi.nlm.nih.gov/pmc/articles/

"Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets"

nature.com/articles/s41467-020

"Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets"

science.org/doi/10.1126/scienc

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