Random insertions are identified by strategically placing the guide RNAs (gRNAs) used in the CRISPR-KRISPR assay: one gRNA in one of the homology arms and the second binding to an overlapping region between the insert and the other arm. See article for more details.
Genome Editor. Co-developer of Easi-CRISPR; http://bit.ly/Easi-CRISPR. World now needs peace and solidarity, not war. Opinions mine.