Hao Yin @HaoYin@qoto.org

#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant

Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1

Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6

Retinal & Choroidal Vasculature in Patients with #MarfanSyndrome

24 case+26 ctrl
#OpticalCoherenceTomography Angiography

⏬(by 3~11%) Microvessel densities in superficial/deep/choriocapillaris plexus

Dr Matteo Di Marino lab Transl Vis Sci Technol 2020
https://tvst.arvojournals.org/article.aspx?articleid=2770566

Retinal arteriopathy in #Marfan🐭
A role of Fibrillin-1 in microvasculature🤠

Arteriolar dilation
Focal #SmoothMuscleCell loss
Leakiness peri-arteriolar albumin
(As early as P6)

Dr Florian Alonso & Elisabeth Génot lab @Biomol_MDPI 2022
https://www.mdpi.com/2218-273X/12/10/1330/htm