"growth is a non-monotonic function of volume in yeast cells, with maximal values around the critical size. Comparing small to normal, large and outsized cells, the transcriptome undergoes an extensive inversion that correlates with RNA polymerase II occupancy. Accordingly, highly expressed genes impose strong negative effects on growth when their DNA/mass ratio is altered. A similar transcriptomic inversion is displayed by mouse liver cells of different sizes [...] cell size is set to attain a properly balanced transcriptome and, hence, maximize growth during cell proliferation."

https://www.biorxiv.org/content/10.1101/2022.11.08.515578v1?rss=1