Society for Glycobiology @SfG@qoto.org

It's great to see this #Caenorhabditis mannosidase III #glycotime manuscript out in @jbiolchem
Product of the @FWF_at project awarded to former postdoc Shi Yan showing how a specific mannosidase is necessary for the biosynthesis of a subset of complicated N-glycans.

https://www.jbc.org/article/S0021-9258(24)02446-3/fulltext

Some exciting #glycotime to start the week!

GlycoShape is fresh off the press today on Nature Methods https://www.nature.com/articles/s41592-024-02464-7

Check out the short thread below 1/6

#Science #ProteinStructure #glycobiology

This month's interesting fact about #glyco covers rare and unusual sugars and monosaccharides like D-tagatose, D-allulose and L-sorbose.

Read more: https://research.bidmc.org/ncfg/blog/facts-about-rare-and-unusual-sugars-nature

For more interesting facts: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans

#glycotime #monosaccharides #carbohydrates

In this month's interesting facts about #glycans we look at the #glycoprotein collagen and its unique #glycosylation

Read the post: https://research.bidmc.org/ncfg/blog/facts-about-collagen-and-its-glycosylation-one-most-common-glycoproteins-all-animals

For more interesting facts check: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans

#glycotime #collagen

New paper accepted!

12-Jul-2024

Journal: Biochemistry
Manuscript ID: bi-2024-00187z.R3
Title: "Bioinformatic, enzymatic and structural characterization of Trichuris suis hexosaminidase HEX-2"
Author(s): Dutkiewicz, Zuzanna; Varrot, Annabelle; Breese, Karen; Stubbs, Keith; Nuschy, Lena; Adduci, Isabella; Paschinger, Katharina; Wilson, Iain

“We are pleased to inform you that your manuscript has been accepted for publication in Biochemistry.”

This month's interesting fact about glycoscience is about #glycopeptides made by bacteria and the importance of #carbohydrates in antibiotics.

Read the full post at: https://research.bidmc.org/ncfg/blog/facts-about-glycopeptides-made-bacteria

For more interesting facts check: https://research.bidmc.org/ncfg/blog

#glycotime #bacteria #antibiotics

Recently Dr. Cummings from the @ncfg published the first ever Periodic Table of Monosaccharides. We thought it would be great to have an interactive version of this as a website, and so we built one.

You can access this at: https://glycotoolkit.com/Tools/periodic-table-of-monosaccharides/

#glycotime #glycotool

This month's interesting fact about glycans discusses the heavily O-glycosylated (specifically O-GlcNAcylated) protein in the nucleus - RNA Polymerase II.

Read the full post at: https://research.bidmc.org/ncfg/blog/facts-about-heavily-glycosylated-protein-nucleus-rna-polymerase-ii

For more interesting facts check: https://research.bidmc.org/ncfg/blog

#glycotime #rna

A spoonful of sugar #11 🍬

As the rest of the community, we have excited about #AF3 and have been testing its performance in the reconstruction of glycans and glycosylation. We have found the following limitations users should be aware of:

- The structure of the Asn-linkages is incorrect

- All N-glycans have an a2 arm, while the Man should be in a3

What we suggest 😜 is to build the protein with AF3 and to reglycosylate it with ReGlyco at https://glycoshape.org

#glycotime

This month on our blog - we highlight facts about cholesterol glycosylation.
Read at: https://research.bidmc.org/ncfg/blog/facts-about-glycosylation-cholesterol

For more interesting facts about glycans check out our page: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans

#glycotime #glycoblog

This month on our blog - we highlight interesting facts about Pectin - One of the Most Complex Polysaccharides in Nature and its Healing Properties.

Read: https://research.bidmc.org/ncfg/blog/facts-about-pectin-one-most-complex-polysaccharides-nature-and-its-healing-properties

For more interesting facts about glycans check out our page: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans

#glycotime #glycans #glycosylation

Elegant study shows how the location and composition of N-glycans (glyco-code) influences protein folding and quality control. Competition between early lectin chaperone and BiP, and the role of UGGT particularly ineteresting.

https://tinyurl.com/wy8487cn

#glycotime

Excited about the #GlycoNMR summit (online meeting) that is just about to start. #NMR analysis of polysaccharides and glycoproteins. The event runs multiple days on zoom, hosted by the University of Georgia. More info and register: https://mailchi.mp/deff7bbeac2e/join-us-for-the-2023-glyconmr-summit #nmrchat #glycotime

Interesting! L-fucose administration ameliorates the LPS-induced neuroinflammation in the Fut8+/− mice, suggesting that core fucosylation plays a vital role in anti-inflammation. L-Fuc as a potential drug against neuroinflammation?

https://tinyurl.com/2c8xtsp3

#glycotime

You have heard of the periodic table of elements-
we present the Periodic Table of Monosaccharides where we attempt to arrange the monosaccharides in a systematic table.

Published in Glycobiology: https://academic.oup.com/glycob/advance-article-abstract/doi/10.1093/glycob/cwad088/7342216?redirectedFrom=fulltext

#glycotime #glycoeducation #glycans #monosaccharides

📢#Glycoscience Community on Mastadon.
Are you attending the Society for Glycobiology meeting in Hawaii? Find us and learn about the work at the NCFG and the Cummings Lab.

1. We are hosting a Satellite meeting on Nov. 5th, entitled: NCFG Tools in Glycoscience, we hope you will be joining us!

2. Come check out our posters at the SFG meeting:
#155, #401, #67, #79, #89, #224, #170, and #225
We have some interesting developments in #glycan #microarrays, #glycomics and other fun stuff!