Hi everyone! #introduction
I’m Katie and I research #endometriosis specifically using #DNAmethylation and #geneexpression to understand mechanisms of #dysmenorrhea. I have a master’s in biostatistics from UMass Amherst and I’m a PhD candidate in human genetics at UCLA currently.
I’m scheduled to defend my dissertation in 5 weeks, so clearly I should be writing!
Instead, I’d rather be discussing #rstats or throwing #pottery or #biking or #baking or posting pictures of my cat! #caturday
@katieleap Do you often see mutations within endometriosis lesions? I’ve always wondered.
Thanks for doing this work! As a endo sufferer it means a lot to me that people are working on this. I really want to start a project on it, but don’t know enough of the science behind it.
@Caitlin_Stewart Yes! Somatic mutations in endometriosis lesions is a current research focus for several groups. Still figuring out how to toot, but I’ll try to link some papers (which use up a lot of characters). The overall gist is that the endometrium is highly mutable, endometriosis lesions show clonal expansion of cancer-driver genes, epithelial cells harbor more mutations than stromal, and mutations are shared across ectopic lesions.
@katieleap @Caitlin_Stewart Wow, I think I just learned more about #endometriosis from your toot than from all the doctors and professors so far.
