Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes https://www.biorxiv.org/content/10.1101/2023.01.11.523607v1?med=mas
Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes https://www.biorxiv.org/content/10.1101/2023.01.11.523558v1?med=mas
Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ https://www.biorxiv.org/content/10.1101/2023.01.10.523497v1?med=mas
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution https://www.biorxiv.org/content/10.1101/2023.01.11.523597v1?med=mas
Accelerated evolution using the phage T7 and its application to evolve riboswitches https://www.biorxiv.org/content/10.1101/2023.01.11.523572v1?med=mas
A role for the proteasome alpha2 subunit N-tail in substrate processing https://www.biorxiv.org/content/10.1101/2023.01.11.523624v1?med=mas
Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation https://www.biorxiv.org/content/10.1101/2023.01.11.523614v1?med=mas
Structure and activity of botulinum neurotoxin X https://www.biorxiv.org/content/10.1101/2023.01.11.523524v1?med=mas
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor https://www.biorxiv.org/content/10.1101/2023.01.10.523504v1?med=mas
Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification https://www.biorxiv.org/content/10.1101/2023.01.11.523441v1?med=mas
Defective transfer of parental histone decreases frequency of homologous recombination in budding yeast https://www.biorxiv.org/content/10.1101/2023.01.10.523501v1?med=mas
Improved enzymatic labeling of fluorescent in situ hybridization probes applied to the visualization of retained introns in cells https://www.biorxiv.org/content/10.1101/2023.01.10.523484v1?med=mas
Branched multimeric peptides as affinity reagents for detection of α-Klotho protein https://www.biorxiv.org/content/10.1101/2023.01.10.523487v1?med=mas
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization https://www.biorxiv.org/content/10.1101/2023.01.11.523589v1?med=mas
Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity https://www.biorxiv.org/content/10.1101/2023.01.11.523580v1?med=mas
Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma https://www.biorxiv.org/content/10.1101/2023.01.11.523553v1?med=mas
The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS https://www.biorxiv.org/content/10.1101/2023.01.10.523522v1?med=mas
Next-generation diarylquinolines improve sterilizing activity of regimens with pretomanid and the novel oxazolidinone TBI-223 in a mouse tuberculosis model https://www.biorxiv.org/content/10.1101/2023.01.10.523519v1?med=mas
Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major https://www.biorxiv.org/content/10.1101/2023.01.10.523530v1?med=mas
Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance https://www.biorxiv.org/content/10.1101/2023.01.11.523617v1?med=mas
The non-profit preprint server for the life sciences