bioRxiv @biorxivpreprint@qoto.org

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice https://www.biorxiv.org/content/10.1101/2023.08.03.551823v1?med=mas

Constitutive activity of ionotropic glutamate receptors via a hydrophobic plug in the ligand-binding domain https://www.biorxiv.org/content/10.1101/2023.08.03.551817v1?med=mas

MultiPPIMI: a multimodal deep learning framework for predicting interactions between protein-protein interaction targets and modulators https://www.biorxiv.org/content/10.1101/2023.08.03.551827v1?med=mas

Conformational diversity and protein-protein interfaces in drug repurposing in Ras signaling pathway https://www.biorxiv.org/content/10.1101/2023.08.03.551801v1?med=mas

Ribosomal DNA copy number is associated with body mass in humans and other mammals https://www.biorxiv.org/content/10.1101/2023.08.03.551775v1?med=mas

A transmission bottleneck for malaria? Quantification of sporozoite expelling from laboratory and natural P. falciparum infections https://www.biorxiv.org/content/10.1101/2023.08.03.551751v1?med=mas

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis https://www.biorxiv.org/content/10.1101/2023.08.04.551982v1?med=mas

Evaluating the transmission risk of amyloid beta peptide via ingestion https://www.biorxiv.org/content/10.1101/2023.08.03.551437v1?med=mas

MEK inhibition enhances the antitumor effect of radiation therapy in NF1-deficient glioblastoma https://www.biorxiv.org/content/10.1101/2023.08.04.552061v1?med=mas

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications https://www.biorxiv.org/content/10.1101/2023.08.05.552134v1?med=mas

Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility https://www.biorxiv.org/content/10.1101/2023.08.03.551847v1?med=mas

Transcriptional control of compartmental boundary positioning during Drosophila wing development https://www.biorxiv.org/content/10.1101/2023.08.05.552106v1?med=mas

Topological stress triggers difficult-to-repair DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment https://www.biorxiv.org/content/10.1101/2023.08.05.552131v1?med=mas

PEX1 is essential for the glycosome biogenesis and trypanosomatid parasite survival. https://www.biorxiv.org/content/10.1101/2023.08.05.550684v1?med=mas

Extracellular filaments revealed by affinity capture cryo-electron tomography of lymphocytes https://www.biorxiv.org/content/10.1101/2023.08.05.552110v1?med=mas

Enterovirus-A71 exploits Rab11 to recruit chaperones for virus morphogenesis https://www.biorxiv.org/content/10.1101/2023.08.05.552141v1?med=mas

Dynamic Regulation of Vesicle Pools in a Detailed Spatial Model of the Complete Synaptic Vesicle Cycle https://www.biorxiv.org/content/10.1101/2023.08.03.551909v1?med=mas

Accelerated social representational drift in the nucleus accumbens in a model of autism https://www.biorxiv.org/content/10.1101/2023.08.05.552133v1?med=mas

Determining the shelf life of an erythropoietin alfa biosimilar GBPD002 through stability study https://www.biorxiv.org/content/10.1101/2023.08.05.552105v1?med=mas

CRISPR-DIPOFF: An Interpretable Deep LearningApproach for CRISPR Cas-9 Off-Target Prediction https://www.biorxiv.org/content/10.1101/2023.08.05.552139v1?med=mas