Christian Mayer

We are excited to present our new study combining in vivo CRISPR perturbation sequencing with barcode-based lineage tracing. Our study reveals a mechanism by which selective enhancer activation establishes the identity of GABAergic projection neurons. This work may help to better understand neurologic disease caused by MEIS2 mutations. Thanks to @Elena_dvoretskova, May, Volker, our collaborators, and
biorxiv.org/content/10.1101/20
#ERC

Spatial enhancer activation determines inhibitory neuron identity

The mammalian telencephalon contains a tremendous diversity of GABAergic projection neuron and interneuron types, that originate in a germinal zone of the embryonic basal ganglia. How genetic information in this transient structure is transformed into different cell types is not yet fully understood. Using a combination of in vivo lineage tracing, CRISPR perturbation and ChIP-seq in mice, we found that the transcription factor MEIS2 favors the development of projection neurons through genomic binding sites in regulatory enhancers of projection neuron specific genes. MEIS2 requires the presence of the homeodomain transcription factor DLX5 to direct its functional activity towards these sites. In interneurons, the activation of projection neuron specific enhancers by MEIS2 and DLX5 is repressed by the transcription factor LHX6. When MEIS2 carries a mutation associated with intellectual disability in humans, it is less effective at activating enhancers involved in projection neuron development. This suggests that GABAergic differentiation may be impaired in patients carrying this mutation. Our research has uncovered a mechanism by which the selective activation of enhancers plays a crucial role in the establishment of neuronal identity, as well as in potential pathological mechanisms. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Christian Mayer boosted
Indigenous Food Circle

A crowd-sourced map for fruit trees on public lands.

#fruit #food #foraging

fallingfruit.org/

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Christian Mayer boosted
David Schoppik

Amazing discovery: how motor neurons come to control fast and slow muscles!

Q: How do developing motor neurons decide to be "fast" (controlling fast-twitch, or "sprinting" muscle fibers) or "slow" (endurance)?

A: Genes called transcription factors determine fast motor neuron "fate." Losing factors make fast neurons project to slow muscle & express "slow motor neuron" genes!

Work from my & Jeremy Dasen's lab: biorxiv.org/content/10.1101/20

Pls boost -- trying to beat that other site 🤷🏻‍♂️😝.

A diagram of a 3 day old zebrafish showing location of spinal cord in purple. Crop of the tail shows the spinal cord at a lateral view. Motor neuron functional subtypes indicated by colors are organized along the dorsoventral axis and by birthdate.
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Christian Mayer boosted
MPI for Biol. Intelligence

Congratulations, Lukas Groschner!

The project leader in Alexander Borst's department receives the Schilling Research Award of the German Neuroscience Society 2023. The prize recognizes his contribution to the understanding of how single neurons perform arithmetic operations.

nwg-info.de/en/careers/awards/

@lukas @MPIforBI
#science #sciencemastodon #neuroscience #award # scienceaward #mpiforbi

Photo: MPI for Biological Intelligence/Axel Griesch

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Christian Mayer boosted
MPI for Biol. Intelligence

Please join us in welcoming our new IMPRS-BI: the International Max Planck Research School – Biological Intelligence!

The program will offer first-rate doctoral positions in the fields of neuroscience, neurotechnology, behavioral ecology, connectomics, and evolutionary genetics. The application portal will open soon, stay tuned!

Find out more: imprs-bi.mpg.de/

#mpiforbi #maxplanck #maxplanckinstitute #imprs #imprsbi #gradschool #graduateschool #phdprogram #phd #phdingermany

Dark green visual with light green text "We welcome" and logo of the International Max Planck Research School - Biological Intelligence
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Christian Mayer boosted
MPI for Biol. Intelligence

Congratulations Christian Mayer for successfully joining the EMBO Young Investigator Programme!
The Mayer group develops new approaches to determine genetic mechanisms underlying the differentiation of inhibitory neurons. Learn more: bi.mpg.de/mayer'
@cmayer
#science #ScienceMastodon #embo #neuroscience #mpiforbi

Portrait picture of Christian Mayer with a banner: Congratulations Christian Mayer, EMBO Young Investigator
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Christian Mayer

I am very excited to announce that my lab will join the Young Investigator Programme. I am greatly honored to have been selected for this program, and I look forward to interacting with the program's research groups.

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Christian Mayer


I am a Max Planck Research Group Leader at the MPI for Biological Intelligence. Our lab explores fundamental questions in developmental related to the generation of cell-type diversity. We combine scRNAseq with lineage barcoding tools and genetic perturbation to explore principles that orchestrate the establishment of neuronal identities.

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