Recently, I watched "Kino no tabi" and while it was mostly quite nice, I cannot help but complain. The short version is: I can recommend it IF you are prepared for the ending, but can't recommend it to the unwarned. (I won't spoil anything except the emotions invoked by the ending.)
The series is about a human (Kino) and a sentient motorcycle (Hermes) travelling through many different city-states, each of which is its own strange, flawed little world.
In general, it's a very interesting, philosophical-ish series.
The general mood of the series is contemplative with undertones of sadness. The ending, on the other hand, devolves into complete and utter depression.
Now of course, the reason I'm complaining is that it made me feel bad, and my reasoning for why it's bad it motivated by that. But there a genuine mismatch with the rest of the series.
What makes it a lot worse is that the ending feels unreasonable. In earlier episodes, there is some kind of logic behind why things are bad, some cause to point to. But for the ending, the only cause presented is characters' own decisions. And those decisions are completely insane - in particularly the character Sakura feels completely unrealistic.
This is also a bit of a problem with the series in general: in its exploration of dystopia, it exaggerates aspects of human behaviour, and the people in the different city-states end up feeling very alien to the audience. Kino and Hermes are the only real people in the series, and even they do not show much character development.
Still, having given my warning about the ending, I can definitely recommend watching it.