jonmoulton @jonmoulton@qoto.org

Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation. https://www.biorxiv.org/content/10.1101/2023.11.07.566007v1 #Morpholino

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01349-0 #Morpholino

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation. https://www.biorxiv.org/content/10.1101/2023.11.08.566201v1 #Morpholino

Optimization and Safety Results of E1v1.11: a #Morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy
https://www.mdaconference.org/abstract-library/optimization-and-safety-results-of-e1v1-11-a-morpholino-antisense-oligonucleotide-therapeutic-for-spinal-muscular-atrophy/

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. https://www.nature.com/articles/s41467-023-42929-5 #Morpholino

Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve Circulation. https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.14239 #Morpholino

Kif21a deficiency leads to impaired glomerular filtration barrier function. https://www.nature.com/articles/s41598-023-46270-1 #Morpholino

Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011010 #Morpholino

The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. https://www.nature.com/articles/s41598-023-47046-3 #Morpholino

Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. https://www.biorxiv.org/content/10.1101/2023.10.30.563773v1 #Morpholino

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. https://www.science.org/doi/10.1126/sciadv.adi4777 #Morpholino

Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. https://www.biorxiv.org/content/10.1101/2023.11.02.565243v1 #Morpholino

Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo. https://www.biorxiv.org/content/10.1101/2023.11.02.565128v1 #Morpholino

Analysis of Vascular Morphogenesis in Zebrafish. https://link.springer.com/protocol/10.1007/978-1-0716-2887-4_24 #Morpholino

Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with #Morpholino Peptide Conjugates. https://pubs.acs.org/doi/10.1021/acsomega.3c05634

Pharma's Almanac: Interview with Jon discussing using #Morpholino oligos to alter splicing. https://www.pharmasalmanac.com/articles/modifying-rna-splicing-with-morpholinos

nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. https://www.cell.com/heliyon/fulltext/S2405-8440(23)09123-5 #Morpholino

Gαi2-Mediated Regulation of Microtubules Dynamics and Rac1 Activity Orchestrates Cranial Neural Crest Cell Migration in Xenopus. https://www.biorxiv.org/content/10.1101/2023.09.07.556733v2 #Morpholino

Siderophore-Mediated Conveyance of Antibacterial-Antisense Oligomers. https://www.biorxiv.org/content/10.1101/2023.10.30.564798v1 #Morpholino

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. https://ashpublications.org/blood/article/doi/10.1182/blood.2023020903/498619/Regulation-of-lymphoid-myeloid-lineage-bias #Morpholino