Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00278-0
A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis? https://journals.sagepub.com/doi/10.1177/25152564231211409 #Morpholino
Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065458 #Morpholino
Biallelic COQ4 Variants in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization. https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.29664 #Morpholino
ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae. https://www.sciencedirect.com/science/article/pii/S1096719223007278 #Morpholino
Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. https://www.science.org/doi/10.1126/sciadv.adh9673 #Morpholino
Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development. https://www.science.org/doi/10.1126/sciadv.adg6532 #Morpholino
Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry. https://www.biorxiv.org/content/10.1101/2023.11.23.568438v1 #Morpholino
Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases. https://www.nature.com/articles/s41467-023-43349-1 #Morpholino
ERBB3 deficiency causes a multisystemic syndrome in human patient and zebrafish. https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.14462 #Morpholino
A collagen-rich arch in the urochordate notochord coordinates cell shaping and multi-tissue elongation. https://www.cell.com/current-biology/fulltext/S0960-9822(23)01515-4 #Morpholino
mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide–PMO Conjugates. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00408 #Morpholino
UGT1A1 morpholino antisense oligonucleotides produce mild unconjugated hyperbilirubinemia in cyclosprin A-induced cardiovascular disorders in BLC57 mice. https://www.sciencedirect.com/science/article/abs/pii/S1382668923002636 #Morpholino
Embryo-scale reverse genetics at single-cell resolution. https://www.nature.com/articles/s41586-023-06720-2 #Morpholino
Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury. https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/abstract #Morpholino
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. https://link.springer.com/article/10.1007/s13346-023-01469-7 #Morpholino
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-023-00331-1
Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. https://www.biorxiv.org/content/10.1101/2023.11.09.566412v1 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.
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