jonmoulton @jonmoulton@qoto.org

Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria. https://onlinelibrary.wiley.com/doi/10.1002/anie.202402405 #Morpholino into Escherichia coli K12 MG1655 and Acinetobacter baumannii (ATCC19606)

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics. https://rnajournal.cshlp.org/content/early/2024/02/27/rna.079969.124.long Delivery of #Morpholino into Salmonella by KFF peptide

Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae135/7614861 #Morpholino

Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function. https://onlinelibrary.wiley.com/doi/10.1002/anie.202318773 #Morpholino

A vertebrate Vangl2 translational variant required for planar cell polarity. https://www.jbc.org/article/S0021-9258(24)01265-1/fulltext #Morpholino

Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo. https://www.biorxiv.org/content/10.1101/2024.02.19.580938v1 #Morpholino

Noncanonical function of folate through folate receptor 1 during neural tube formation. https://www.nature.com/articles/s41467-024-45775-1 #Morpholino

Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression. https://pubs.acs.org/doi/10.1021/acsinfecdis.3c00645 #Morpholino

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells. https://www.nature.com/articles/s41419-024-06507-x Vivo-#Morpholino

Investigation of the pathogenesis of ADAR1 gene in dyschromatosis symmetrica hereditaria. https://onlinelibrary.wiley.com/doi/10.1111/exd.15031 #Morpholino

Protocol for tail vein injection in Xenopus tropicalis tadpoles. https://www.sciencedirect.com/science/article/pii/S2666166724000601?via%3Dihub Vivo-#Morpholino

Long-range chemical signalling in vivo is regulated by mechanical signals. https://www.biorxiv.org/content/10.1101/2024.02.15.580459v1 #Morpholino

FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System. https://www.ahajournals.org/doi/suppl/10.1161/CIRCULATIONAHA.123.064489 #Morpholino

Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications. https://www.sciencedirect.com/science/article/pii/S2666247724000137 #Morpholino

Localization and function of key axonemal microtubule inner proteins and dynein docking complex members reveal extensive diversity among vertebrate motile cilia. https://www.biorxiv.org/content/10.1101/2024.02.14.580281v1 #Morpholino

Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae093/7608825 #Morpholino

Apela promotes blood vessel regeneration and remodeling in zebrafish. https://www.nature.com/articles/s41598-023-50677-1 #Morpholino

(AJMC Article): Positive Phase 2 Data for SRP-5051 in Duchenne Muscular Dystrophy https://www.ajmc.com/view/positive-phase-2-data-for-srp-5051-in-duchenne-muscular-dystrophy #Morpholino

Cell contacts and pericellular matrix in the Xenopus gastrula chordamesoderm. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0297420 #Morpholino

Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos. https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP285490
#Morpholino