An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. https://onlinelibrary.wiley.com/doi/10.1111/cpr.13594 #Morpholino
Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. https://www.nature.com/articles/s41467-023-43544-0 #Morpholino
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus. https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awad405/7490822 #Morpholino
CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. https://www.nature.com/articles/s41598-023-50065-9 #Morpholino
CLEC12A sensitizes differentially responsive breast cancer cells to the anti-cancer effects of artemisinin by repressing autophagy and inflammation. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1242432/full #Morpholino
Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. https://www.sciencedirect.com/science/article/abs/pii/S0378111923009460 #Morpholino
Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish. https://www.jthjournal.org/article/S1538-7836(23)00877-2/pdf #Morpholino
The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.123.323231 #Morpholino
Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation. https://www.sciencedirect.com/science/article/pii/S0021925823025899 #Morpholino
CKAP5 enables formation of persistent actin bundles templated by dynamically instable microtubules. https://www.cell.com/current-biology/pdf/S0960-9822(23)01581-6.pdf #Morpholino
Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis. https://www.biorxiv.org/content/10.1101/2023.12.01.569622v1 #Morpholino
Ruvbl1 is Essential for Ciliary Beating during Xenopus laevis Embryogenesis. https://www.ksdb.org/archive/view_article?pid=dr-27-3-159 #Morpholino
Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01760-6 #Morpholino
Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295711 #Morpholino
The role of MAPRE2 and microtubules in Brugada syndrome pathogenesis. https://academic.oup.com/eurheartj/article/44/Supplement_2/ehad655.3059/7390948 #Morpholino
Networking to Optimize Dmd exon 53 Skipping in the Brain of mdx52 Mouse Model. https://www.mdpi.com/2227-9059/11/12/3243 #Morpholino
Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration. https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261332/336525/Inactivating-negative-regulators-of-cortical #Morpholino
Transmembrane protein 14A protects glomerular filtration barrier integrity. https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15847 #Morpholino
A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011665 #Morpholino
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. https://www.nature.com/articles/s41467-023-43851-6 #Morpholino
It's been all Morpholinos all the time for about 23 years. I'm a scientist with Gene Tools LLC.