jonmoulton @jonmoulton@qoto.org

Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression. https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.201460/308861/Voltage-gated-sodium-channel-activity-mediates-sea #Morpholino

BMP signaling is required to form the anterior neural plate border in ascidian embryos. https://link.springer.com/article/10.1007/s00427-023-00702-0 #Morpholino

The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. https://www.life-science-alliance.org/content/6/7/e202302023 #Morpholino

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00430-9 #Morpholino

Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. https://www.discovmed.com/EN/10.24976/Discov.Med.202335175.15 #Morpholino

Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01599-x #Morpholino

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. https://elifesciences.org/articles/85902 #Morpholino

The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. https://onlinelibrary.wiley.com/doi/10.1002/advs.202205345 #Morpholino

Upcoming Gene Tools exhibits:

Association for Research in Vision and Ophthalmology (ARVO), 23Apr-27Apr, New Orleans LA
Jon will be at ARVO in NOLA.

AAPS National Biotechnology Conference, 23Apr-26Apr, Philadelphia PA
It's Brandy's turn for Philadelphia.

#Morpholino

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. https://www.nature.com/articles/s41467-023-37928-5 #Morpholino

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. https://www.biorxiv.org/content/10.1101/2023.04.15.537039v1
#Morpholino

Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides. https://www.biorxiv.org/content/10.1101/2023.04.14.536849v1 #Morpholino

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial. https://onlinelibrary.wiley.com/doi/abs/10.1002/npr2.12335 #Morpholino

Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. https://www.nature.com/articles/s41467-023-37745-w #Morpholino

TAR Syndrome-associated Rbm8a deficiency causes hematopoietic defects and attenuates Wnt/PCP signaling. https://www.biorxiv.org/content/10.1101/2023.04.12.536513v2 #Morpholino

Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999. https://www.nature.com/articles/s41467-023-37819-9 #Vivo-Morpholino

A Realistic Mixture of Persistent Organic Pollutants Affects Zebrafish Development, Behavior, and Specifically Eye Formation by Inhibiting the Condensin I Complex. https://www.mdpi.com/2305-6304/11/4/357 #Morpholino

Zebrafish dnm1a gene plays a role in the formation of axons and synapses in the nervous tissue. https://onlinelibrary.wiley.com/doi/full/10.1002/jnr.25197 #Morpholino

Enhancement of zebrafish sperm production via a large body-sized surrogate with germ cell transplantation. https://www.nature.com/articles/s42003-023-04800-7 #Morpholino

miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. https://journals.lww.com/hepcomm/Fulltext/2023/04010/miR_34a_regulates_macrophage_associated.41.aspx #Morpholino