jonmoulton @jonmoulton@qoto.org

Correction of Clcn1 alternative splicing reverses muscle fiber type transition in mice with myotonic dystrophy. https://www.nature.com/articles/s41467-023-37619-1 #Morpholino

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. https://www.pnas.org/doi/10.1073/pnas.2214997120 #Morpholino

The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation. https://www.molbiolcell.org/doi/10.1091/mbc.E22-09-0411 #Morpholino

Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System.
https://www.mdpi.com/1422-0067/24/7/6804 #Morpholino

Long noncoding RNA HIKER regulates erythropoiesis in Monge’s disease via CSNK2B. https://www.jci.org/articles/view/165831 #Morpholino

Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00362-5 #Morpholino

Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity. https://www.nature.com/articles/s41422-023-00797-0 #Morpholino

Characterization of regeneration initiating cells during Xenopus laevis tail regeneration. https://www.biorxiv.org/content/10.1101/2023.03.30.534908v1 #Morpholino

Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration. https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.569 #Morpholino

Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via aberrant mitophagy activation. https://jmg.bmj.com/content/early/2023/04/02/jmg-2022-108888 #Morpholino

Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. https://www.mdpi.com/2079-7737/12/4/538 #Morpholino

Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length. https://pubs.acs.org/doi/10.1021/acs.est.2c09716 #Morpholino

BDNF signaling in correlation-dependent structural plasticity in the developing visual system. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002070 #Morpholino

Abnormal autophagy is a critical mechanism in TANGO2-related rhabdomyolysis. https://www.biorxiv.org/content/10.1101/2023.03.29.534583v1 #Morpholino

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. https://elifesciences.org/articles/83652 #Morpholino

Inhibition of Interferon Alpha by a Peptide-Conjugated Phosphorodiamidate #Morpholino Oligomer Increases Influenza Virus Replication in Chicken Embryo Fibroblast (DF-1) Cells; An Alternative Strategy to Increasing Vaccine Production in Cell Culture. https://ssrn.com/abstract=4057449

Her6 and Prox1 are novel regulators of photoreceptor regeneration in the zebrafish retina https://www.biorxiv.org/content/10.1101/2023.03.20.532714v1 #Morpholino

I'm guest editing a topic collection for Frontiers in Genetics (@FrontGenetics). Anyone have new #Morpholino gymnastics to offer?
Frontiers research topic: Steric-blocking Oligos Changing and Probing RNA Processes
https://www.frontiersin.org/research-topics/52581/steric-blocking-oligos-changing-and-probing-rna-processes

In Vivo Evaluation of Exon 51 Skipping in hDMD/Dmd-null Mice. https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_23 #Morpholino

Exons 45–55 Skipping Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells.
https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_22 #Morpholino