jonmoulton @jonmoulton@qoto.org

An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate #Morpholino oligomers https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001807

(Fish Diseases conference program) Learning more from knockdowns and knockouts https://fish-models.com/gene-tools/ #Morpholino

Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family. https://www.sciencedirect.com/science/article/abs/pii/S0145305X24000156 #Morpholino

Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance. https://www.mdpi.com/1422-0067/25/4/2079 Vivo-#Morpholino

Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development. https://www.nature.com/articles/s41375-024-02165-2 #Morpholino

Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator. https://elifesciences.org/articles/80803 #Morpholino

Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.3c00924 #Morpholino

Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes. https://www.nature.com/articles/s10038-024-01222-z #Morpholino

Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation. https://www.e-neurospine.org/journal/view.php?doi=10.14245/ns.2347238.619 #Morpholino

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. https://www.tandfonline.com/doi/full/10.1080/27694127.2024.2306766 #Morpholino

Endocardium gives rise to blood cells in zebrafish embryos. https://www.sciencedirect.com/science/article/pii/S2211124724000640 #Morpholino

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient. https://www.nature.com/articles/s41467-024-44951-7 #Morpholino

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis. https://www.frontiersin.org/articles/10.3389/fcell.2024.1316048/abstract #Morpholino

Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. https://www.sciencedirect.com/science/article/abs/pii/S0091679X22001455 Vivo-#Morpholino

Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina. https://journals.biologists.com/dev/article-abstract/151/2/dev201463/342422/Awakening-adult-neural-stem-cells-NOX-signalling #Morpholino

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. https://ehoonline.biomedcentral.com/articles/10.1186/s40164-023-00468-1
#Morpholino

Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development. https://www.biorxiv.org/content/10.1101/2024.01.26.577434v1 #Morpholino

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease. https://preprints.org/manuscript/202401.1959/v1 #Morpholino

Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. https://www.nature.com/articles/s41598-024-52530-5 #Morpholino

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. https://www.sciencedirect.com/science/article/abs/pii/S0006291X2400086X #Morpholino