jonmoulton @jonmoulton@qoto.org

Cryo-EM structure of the Mon1–Ccz1–RMC1 complex reveals molecular basis of metazoan RAB7A activation. https://www.pnas.org/doi/10.1073/pnas.2301725120 #Morpholino

Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo. https://journals.biologists.com/bio/article/12/5/bio059783/310414/Actin-filaments-accumulated-in-the-nucleus-remain
Fluorochrome-labeled #Morpholino used as a diagnostic probe in a zebrafish to visualize transcription of the miRNA mir-430

Functional characterization of stap2b in zebrafish vascular development. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201314RRR #Morpholino

A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription. https://www.sciencedirect.com/science/article/pii/S1097276523003854 #Morpholino

Recruitment of transcription factor ETS1 to activated accessible regions promotes the transcriptional program of cilia genes. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad506/7199338 #Morpholino

Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. https://link.springer.com/article/10.1007/s12079-023-00775-6 #Morpholino

A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression. https://www.sciencedirect.com/science/article/pii/S0021925823019488 #Morpholino

Macrophage Migration Inhibitory Factor on Apoptotic Extracellular Vesicles Regulates Compensatory Proliferation. https://www.biorxiv.org/content/10.1101/2023.06.14.544889v1 #Morpholino

Aquaporins enriched in endothelial vacuole membrane regulate the diameters of microvasculature in hyperglycemia. https://www.biorxiv.org/content/10.1101/2023.01.23.525218v2 #Morpholino

NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002121 #Morpholino

In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss. https://www.biorxiv.org/content/10.1101/2023.06.07.544128v1 #Morpholino

Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3. https://www.science.org/doi/10.1126/sciadv.adg0183 #Morpholino

Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism. https://pubs.acs.org/doi/10.1021/acschembio.3c00027 #Morpholino

Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200863/265709/Sfxn5-Regulation-of-Actin-Polymerization-for #Morpholino

Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs).
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad415/7177882
#Morpholino antibody conjugates

The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. https://www.sciencedirect.com/science/article/pii/S0753332223007424 #Morpholino

Plexina4 and cell survival in the developing zebrafish hindbrain. https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.633 #Morpholino

Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. https://www.sciencedirect.com/science/article/abs/pii/S0012160623000945 #Morpholino

Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. https://www.frontiersin.org/articles/10.3389/fgene.2023.1186882/full #Morpholino

Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivity in vivo. https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1176864/full #Morpholino