jonmoulton @jonmoulton@qoto.org

Crb3 is required to organize the apical domain of multiciliated cells. https://journals.biologists.com/jcs/article-abstract/doi/10.1242/jcs.261046/333513/Crb3-is-required-to-organize-the-apical-domain-of #Morpholino

Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. https://onlinelibrary.wiley.com/doi/10.1002/mabi.202300375 #Morpholino

Chaperone-mediated autophagy protects against hyperglycemic stress. https://www.tandfonline.com/doi/figure/10.1080/15548627.2023.2267415 #Morpholino

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. https://link.springer.com/article/10.1007/s00018-023-04933-2 #Morpholino

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. https://www.biorxiv.org/content/10.1101/2023.10.05.561099v2 #Morpholino

P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients. https://www.nmd-journal.com/article/S0960-8966(23)00336-X/pdf #Morpholino

P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model. https://www.nmd-journal.com/article/S0960-8966(23)00330-9/pdf #Morpholino

SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells. https://academic.oup.com/jes/article/7/Supplement_1/bvad114.933/7290239 #Morpholino

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. https://www.nature.com/articles/s41467-023-41836-z #Morpholino

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. https://www.nature.com/articles/s41598-023-43662-1 #Morpholino

(Video): New Exon Skipping Drug in Clinical Development for Duchenne Muscular Dystrophy: Steve Hughes, MD, chief medical officer at AvidityBiosciences https://www.youtube.com/watch?v=XV56y_bwBZM PMO are #Morpholino

Purine Biosynthesis Pathways Are Required for Myogenesis in Xenopus laevis. https://www.mdpi.com/2073-4409/12/19/2379 #Morpholino

A digital twin reproducing gene regulatory network dynamics of early Ciona embryos indicates robust buffers in the network. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010953 #Morpholino

Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension. https://elifesciences.org/reviewed-preprints/91199v1 #Morpholino

A bioelectrical phase transition patterns the first vertebrate heartbeats. https://www.nature.com/articles/s41586-023-06561-z #Morpholino

Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. https://www.mdpi.com/2073-4409/12/18/2309 #Morpholino

Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes. https://www.mdpi.com/1422-0067/24/18/14324 #Morpholino

Hand2 represses non-cardiac cell fates through chromatin remodeling at cis-regulatory elements. https://www.biorxiv.org/content/10.1101/2023.09.23.559156v1 #Morpholino

Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity. https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01288-w #Morpholino

Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis. https://www.nature.com/articles/s41598-023-42868-7 #Morpholino