An interesting point on
“.... How do we truly define a today? ... Are making the “wrong” kinds of molecules?
Or have we entered a new era of drug modalities?
.... And just to prove chemists can continue to make the “right” kinds of molecules, here are some recent low Mw drug -
-       Tecfidera (Mw 144), approved 2013
-       Tavaborole (Mw 151), FDA approved 2014
-       Avibactam (Mw 265), FDA approved 2015
-       Benznidazole (Mw 260), FDA approved 2017
-       Migalastat (Mw 163), FDA approved 2018
 
How many novel small molecule drugs Mw<300 are yet to be discovered?”

linkedin.com/posts/trevor-bret

@marcoradi On the other hand, large molecules are chanting 'the-larger-the-merrier', from mAb to bispecific to trispecific...

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@MingqingCai but the small-molecules are humble fellows and don’t brag about their merits becasuse they know that less is more...

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