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At #PMQs Sunak tells us to "remember the context" re PPE Tory "VIP" scandal - but we do remember the context, people being selfless, helping one another - making it even worse that Ministers were helping mates seeking a fast buck whilst failing to respond to real offers of help

🐦🔗: n.respublicae.eu/CarolineLucas

Jo MH, et al. Single-molecule characterization of subtype-specific β1 integrin mechanics. Nat Commun. 2022 Dec 3;13(1):7471. PMID: 36463259

Wang H, et al. Talin and vinculin combine their activities to trigger actin assembly. bioRxiv posted 1 December 2022 doi:10.1101/2022.12.01.518757. biorxiv.org/cgi/content/abstra

Bugiardini E, et al. Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice. J Am Heart Assoc. 2022 Nov 29;:e026494. [Epub ahead of print] PMID: 36444867

Wallace M, et al. The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope accessibility. bioRxiv posted 22 November 2022 doi:10.1101/2022.11.22.517482. biorxiv.org/cgi/content/abstra

Lee Y-R J, et al. Phase transition of tensin-1 during the focal adhesion disassembly and cell division. bioRxiv posted 17 November 2022 doi:10.1101/2022.11.16.516818. biorxiv.org/cgi/content/abstra

Melamed S, et al. Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. bioRxiv posted 17 November 2022 doi:10.1101/2022.11.16.516843. biorxiv.org/cgi/content/abstra

Zhang Z, et al. Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation. Nat Commun. 2022 Nov 11;13(1):6854. PMID: 36369425

Usman OH, et al. Differential roles of extracellular matrix proteins on primary and metastatic pancreatic cancer cells. bioRxiv posted 13 November 2022 doi:10.1101/2022.11.11.516201. biorxiv.org/cgi/content/abstra

Austin J, et al. Vinculin transmits high-level integrin tensions which are dispensable for focal adhesion formation. Biophys J. 2022 Nov 8;. [Epub ahead of print] PMID: 36352785

Bera K, et al. Extracellular fluid viscosity enhances cell migration and cancer dissemination. Nature. 2022 Nov 2;. [Epub ahead of print] PMID: 36323783

Very cool study from the Garcia-Manyes Lab (TheCrick) exploring the previously dark side of the energy landscape of talin’s R3 domain using magnetic tweezers! Tapia-Rojo et al. observe new rare conformational states, beyond being binary, some of them capable of binding vinculin. These states may encode a new layer of mechanosensitivity in talin's R3 domain! #mechanobiology #biophysics

nature.com/articles/s41567-022
nature.com/articles/s41567-022

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