At #PMQs Sunak tells us to "remember the context" re PPE Tory "VIP" scandal - but we do remember the context, people being selfless, helping one another - making it even worse that Ministers were helping mates seeking a fast buck whilst failing to respond to real offers of help
🐦🔗: https://n.respublicae.eu/CarolineLucas/status/1600473454712860673
Wang H, et al. Talin and vinculin combine their activities to trigger actin assembly. bioRxiv posted 1 December 2022 doi:10.1101/2022.12.01.518757. http://biorxiv.org/cgi/content/abstract/2022.12.01.518757v1
Wallace M, et al. The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope accessibility. bioRxiv posted 22 November 2022 doi:10.1101/2022.11.22.517482. http://biorxiv.org/cgi/content/abstract/2022.11.22.517482v1
Lee Y-R J, et al. Phase transition of tensin-1 during the focal adhesion disassembly and cell division. bioRxiv posted 17 November 2022 doi:10.1101/2022.11.16.516818. http://biorxiv.org/cgi/content/abstract/2022.11.16.516818v1
Melamed S, et al. Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. bioRxiv posted 17 November 2022 doi:10.1101/2022.11.16.516843. http://biorxiv.org/cgi/content/abstract/2022.11.16.516843v1
Usman OH, et al. Differential roles of extracellular matrix proteins on primary and metastatic pancreatic cancer cells. bioRxiv posted 13 November 2022 doi:10.1101/2022.11.11.516201. http://biorxiv.org/cgi/content/abstract/2022.11.11.516201v1
Very cool study from the Garcia-Manyes Lab (TheCrick) exploring the previously dark side of the energy landscape of talin’s R3 domain using magnetic tweezers! Tapia-Rojo et al. observe new rare conformational states, beyond being binary, some of them capable of binding vinculin. These states may encode a new layer of mechanosensitivity in talin's R3 domain! #mechanobiology #biophysics
https://www.nature.com/articles/s41567-022-01808-4
https://www.nature.com/articles/s41567-022-01828-0
Professor of Biochemistry, University of Manchester