Martin Humphries @mqbsswmh@qoto.org
Professor of Biochemistry, University of Manchester
Joined Nov 2022
Saraswathibhatla A, et al. Cell-extracellular matrix mechanotransduction in 3D. Nat Rev Mol Cell Biol. 2023 Feb 27;. [Epub ahead of print] PMID: 36849594
Kumari R, et al. Specialized actin nanoscale layers control focal adhesion turnover. bioRxiv posted 15 February 2023 doi:10.1101/2023.02.15.528622. http://biorxiv.org/cgi/content/abstract/2023.02.15.528622v1
Cheng L-C, et al. Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope. bioRxiv posted 14 February 2023 doi:10.1101/2023.02.13.528342. http://biorxiv.org/cgi/content/abstract/2023.02.13.528342v1
Ganguli S, et al. Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation. bioRxiv posted 12 January 2023 doi:10.1101/2023.01.12.523730. http://biorxiv.org/cgi/content/abstract/2023.01.12.523730v1
Grandy C, et al. Cell shape and tension alter focal adhesion structure. Biomater Adv. 2023 Jan 3;145:213277. [Epub ahead of print] PMID: 36621197
Smith MA, et al. Nuclear pore complexes concentrate on Actin/LINC/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner. Heliyon. 2022 Dec;8(12):e12147. PMID: 36619427
Storey EC & Fuller HR. Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
Cells. 2022 Dec 15;11(24). PMID: 36552829
Zagelbaum J, et al. Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nat Struct Mol Biol. 2022 Dec 23;. [Epub ahead of print] PMID: 36564591
Martin Humphries
boosted
RT @samhaselby@twitter.com
Did the first Americans arrive 15,000 years ago, 40,000 years ago, or 130,000 years ago? Geneticists and archeologists are working with indigenous peoples to try to figure it out. The great @JenniferRaff@twitter.com gives us a glimpse of how it is going. https://aeon.co/essays/the-first-americans-a-story-of-wonderful-uncertain-science via @aeonmag@twitter.com
🐦🔗: https://twitter.com/samhaselby/status/1605896471936647168
Huo T, et al. Full-length {alpha}IIb{beta}3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture. bioRxiv posted 19 December 2022 doi:10.1101/2022.12.19.520944. http://biorxiv.org/cgi/content/abstract/2022.12.19.520944v1
Kumar S, et al. Focal adhesion assembly requires phosphorylation signaling. bioRxiv posted 19 December 2022 doi:10.1101/2022.12.19.521109. http://biorxiv.org/cgi/content/abstract/2022.12.19.521109v1
Martin Humphries
boosted
Hi #ScienceMastodon. We, at #J_Cell_Sci, are a #community journal covering all areas of #cellbiology. We also host the microscopy community site @focalplane_jcs. Journal of Cell Science is led by Editor-in-Chief Michael Way & published by the not-for-profit @Co_Biologists.
We will toot about our content, including #research papers, #reviews, #interviews, charitable activities, and news from @focalplane_jcs.
Toots by Senior Editor Petra Gross & Executive Editor @seemasainson
Martin Humphries
boosted
RT @spirochrome@twitter.com
We are thrilled to announce that the outstanding mitochondrial probes PKmito ORANGE , RED and DEEP RED will be available at Spirochrome from January 2023.
Read more in the fresh article from Zhixing Chen and Stefan Jakobs labs out in @PNASNews@twitter.com
https://doi.org/10.1073/pnas.2215799119
🐦🔗: https://twitter.com/spirochrome/status/1605107353611010050
Martin Humphries
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Been five days since Twitter suspended a bunch of journalists, including me, for tweeting out factual reporting. And we're still suspended.
CNN's @donieosullivan, NYT's Ryan Mac and I can't access Twitter until we delete specific tweets that they said included "private information" but were actually just reporting.
Journalists Linette Lopez and Susan Li, who also covered Musk, are still suspended. No explanation given.
Martin Humphries
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Martin Humphries
boosted
Carl Sagan passed away #OTD in 1996. In his final interviews he left us with two messages that are even more relevant today: one emphasizing the importance of a science literate public, the other a warning about how hard it is to extract ourselves when we’ve been conned.
Niu J, et al. Perinuclear force regulates SUN2 dynamics and distribution on the nuclear envelope for proper nuclear mechanotransduction. bioRxiv posted 19 December 2022 doi:10.1101/2022.12.16.520837. http://biorxiv.org/cgi/content/abstract/2022.12.16.520837v1
Interviews for the next Executive Chair of BBSRC today in BEIS offices. At least I managed to get to Euston on time!
Another phase separation paper to read. Hope the evidence is better this time. Wang B, et al. PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling. bioRxiv posted 18 December 2022 doi:10.1101/2022.12.17.520852. http://biorxiv.org/cgi/content/abstract/2022.12.17.520852v1
Noordstra I, et al. An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. bioRxiv posted 14 December 2022 doi:10.1101/2021.07.28.454239. http://biorxiv.org/cgi/content/abstract/2021.07.28.454239v2
Girardello R, et al. Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells. bioRxiv posted 14 December 2022 doi:10.1101/2022.12.13.520222. http://biorxiv.org/cgi/content/abstract/2022.12.13.520222v1
Martin Humphries
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There are four schools of thought that each have their own ideas on how scientific peer review can be improved. Wolfgang Kaltenbrunner, @stephenpinfield, Helen Woods and I have revised our paper on this topic https://doi.org/10.31235/osf.io/v8ghj. We have also created a visualization that summarizes the key tensions between the four schools. We are grateful to the reviewers of our paper for their very useful feedback.
Professor of Biochemistry, University of Manchester
Joined Nov 2022
