phaseq @routez@qoto.org

美国心理学会期刊《心理学评论》发表了一篇论文，研究结论是过好一生(good life)并不意味着 1. 富足、舒适和活跃的社交，也并非 2. 寻找人生使命与实现价值，而是做到精神丰富（psychologically rich）。精神丰富的人生要有精彩的体验，在或新奇或曲折的经历中人的观念也会发生深刻的改变（interesting experiences in which novelty and/or complexity are accompanied by profound changes in perspective）。

这些体验包括出国留学、选择一条更难的职业道路、体验前卫的艺术（论文所举的例是乔伊斯的《尤利西斯》）。更重要的一个发现是，这种体验不一定要是愉快体验。战乱、自然灾害、膝下无孩、慢性病痛、失业（or出生在洼地）……即使备受煎熬，也可从中收获价值，重塑自己对于自我和世界的理解。

把精神丰富纳入对美好生活的构想，挑战和困难也就有了意义。一帆风顺并非生活本义，山重水复疑无路也有它的价值。（Adding psychological richness to our conceptions of what a good life can look like, Westgate says, is important because it “makes room for challenge and difficulty. It’s not just about ‘everything going well and smoothly.’ Stretching and going through uncomfortable experiences, there is value in that.”）

https://qz.com/2049935/what-does-a-good-life-look-like/

https://www.biorxiv.org/content/10.1101/2022.12.21.521373v1 BioNumPy: Fast and easy analysis of biological data with Python

It's deeply concerning to see signs that many countries around the world are moving from viewing the virus as a Pandemic to accepting it's Endemic. In other words, it's here for decades or longer. "Let it rip" has been a disastrous failure of government public health policy because "hybrid immunity" is a myth. It always was.

Our best hope of eradicating the virus in our lifetime is development of an omnivalent COVID vaccine. That said, it's more likely that permanent protection from COVID will instead be an option that's taken-up only by people who are well-off, educated, and not immune-compromised.

For those who still look at stats, roughly speaking, it seems like the Reff is hovering around 1.0 with fluctuations from approximately 0.8 to 1.2 depending on seasonal cycles and the yearly social/work/school calendar. I know a number of people who've caught COVID two or three times, and I'm certain that some of them are catching it again right now now due at xmas/NYE events and holiday travel.

For the foreseeable future, the majority of people will catch COVID once or twice a year. It's like how people think it's "normal" to catch a serious cold or the flu every year. It's because people aren't taking enough precautions with masks and isolation, and governments and business aren't working to set good standards for ventilation.

Getting sick with COVID carries about a 20% chance of it leading to chronic illness or some form of Long COVID. Catching COVID multiple times means you gamble and roll the dice every time to see if you get Long COVID.

In 2023, it's important that you keep-up:
- Wearing a mask when indoors in public.
- Working from home if possible.
- Doing a RAT if you have any symptoms.
- Caring about people with chronic illness.

#COVID #COVID19 #COVID19Aus #CovidIsNotOver #Pandemic #Endemic #COVIDEndemic #LetItRip #LongCOVID #HybridImmunity

隔三差五就要看到完全否定动物园意义的人忍不住想说一下，中国的情况没有任何代表意义，它宣称的太多东西实际上不都是相反的吗，动物园也不例外。真正的动物园恰恰承担的就是救助、教育工作，它救援被人伤害无法回归野外的动物，给它们提供良好的条件，在保障它们自身福利优先的前提下对外开放游览，而游览中也以教育和公益为目的，除了科普大众知识外，盈利也进一步用于野生动物的救援保护工作。人类的文明程度是一个很虚幻的概念，一个切面不能代表全部，特别是中国这种极端案例。动物表演本来就是现代动物园理念中坚定抵制的内容。国外有很多动物福祉、游览、救助等等都做得非常好的动物园。如果说一个理想化的世界，可能是没有动物园的，但那个世界还很遥远。如果不认识到动物园的真正意义、没有做更多功课就只觉得动物园不该存在的话，更无法到达那个世界。受到人类伤害的动物人类有义务救助他们，教育和启蒙需要时间，动物园承担的就是这个桥梁的作用。否则全靠完全无法盈利的公益组织吗？野生动物纪录片难道就没有道德问题吗？不用说畜牧养殖宠物等等，人类和动物和自然的关系不是简单的取消“野蛮”的动物园就能神奇解决的。

有很多相关的资料可以去了解真正动物园的理念，我也只是稍微集中看过一些东西而已，可能讲的也不完全对。有一部纪录片《方舟后裔》（The Heirs to the Ark），一篇非常有名的文章《如何展示一只牛蛙》（1968年），国内也有很多做动物和动物园相关科普的自媒体人，也有一些较为用心较为现代的动物园。然而整体环境在这里。总的来说我们普遍容易接收到的知识距离现代社会太远以至于空想出来的反驳实际上都脱离不出被限制的框架。并不是没有路的。我们对动物园这个概念的印象，可能已经落后了文明世界半个世纪以上。

最近也发现一个非常好的动物园，有自己的YouTube频道，动物们生活质量都很高，视频非常好看，随便贴一个收藏的链接吧 https://youtu.be/s6kNKbLG28c （不过在它评论区我也看到说动物园不该存在这种声音，但也承认这家动物园很好。只能说教育工作依旧任重道远。）

Wie diese tollen Tierfotos entstehen, die man oft im Internet sieht.

看国内有人在试图自购辉瑞的Paxlovid给老人吃，在此想提醒大家一句，这个药是很严格的处方药，一定要看好标签在吃啊。

很多人都知道这个药需要早用，其实还有一个更加容易忽略的是药物相互作用。Paxlovid含有两个成分，其中一个ritonavir，这是一个很强的药物代谢抑制剂，可以抑制人体最最重要的药物代谢酶。和抗艾滋病的鸡尾酒疗法一样，加入这个成分就是为了利用它抑制代谢的能力来延长其它药物作用。

考虑到Paxlovid使用人群可能存在复杂的合用药物情况，这个时候不仅仅要看Paxlovid的禁用药，还需要研究一下合用药标签，看看强代谢酶抑制剂是不是会影响这些药物。比如，老年人非常常用的抗胆固醇药物里面，Paxlovid标签提到了不能合用辛伐他汀，没有提其它他汀的事情；但是你要去看看用的更广的阿托伐他汀，你就会发现强代谢酶抑制剂会干扰这个药的代谢，这个时候可能需要把阿托暂停，或至少降低剂量，以免出现他汀过量而导致不了反应。

A nice visualization and explanation of some economically relevant math: https://pudding.cool/2022/12/yard-sale/

Great Figure in the supplemental

A crash course/review of doing statistics in Python instead of R.

I recently spent some time translating my knowledge for a lot of data processing and stats work from R back to Python as I'll be rotating in a Python lab this term. I made three references which I'm posting here in case they're helpful for anyone else:

https://thadryanjs.github.io/posts/2022-12-13-from-r-to-python-1/

https://thadryanjs.github.io/posts/2022-12-13-from-r-to-python-2/

https://thadryanjs.github.io/posts/2022-12-13-from-r-to-python-3/

#python #rstats #datascience #research #statistics #data #programming

@academicchatter @phdlife

Finally my #introduction. I am #bioinformatician aspiring to do more #datascience, having my first experience in a Biotech startup.

I like to code, self-taught, ahd work mostly with #RStats, but have dabbled in #python and love the #linux command-line.

My background is in experimental (neuro)biology with a transition to #genomics and #transposon / small RNA biology later on. My CV is best captured in this plot done 100% with code.

http://adomingues.github.io/2020/11/25/visual-cv/

Would you like to learn from some of the best microscopists 🔬 the nuts & bolts of light #microscopy for #lifescience applications? If so, you should check out this free comprehensive #iBiology series with presentations by #RonVale @kurtthorn #NicoStuurman #StefanHell #DanielFletcher #JeffLichtman #EdwardSalmon #ShinyaInoue #RogerTsien & many more covering topics ranging from #imagingformation, #fluorescence, #superresolution & #lightsheet #microscopy to #Optogenetics 👉 https://www.ibiology.org/online-biology-courses/microscopy-series/

Genius concept 😍🤓 — a conference for all the tough topics in #DataScience and #ML we all struggle with but nobody talks about in public. 👉 normconf.com #NormConf

Sampled talk titles:
➡️Five semesters of linear algebra and all I do is solve Python dependency problems (Tim Hopper)
➡️Data ethics: the non-sexy parts (Roy Keyes)

And maaany more!!! 👀 👇👇👇

links to mastodon now look like this on #twitter #elonmusk #bloodythursday

Alyssa's leukemia went into remission by 1 month, and is clear 6 months later🤞. 9 more patients to follow. Much gratitude to Alyssa & her family, Waseem's team, Alexis Komor (@KomorLab@twitter.com) who led the development of CBE as a postdoc in our lab, & many others who paved this path.3/3