Loren Looger, legendary protein wrangler, who always generously shared their genetically encoded calcium indicators and more while still in development and unpublished, is asking for labs to co-write grants with him:

"Dear science world, I need help, please. If you like the tools and data we generate, and our shareware attitude, can you please co-apply for funding with us? It turns out that I'm terrible at writing grants, and we need $$ or else we can't make more GCaMPs, RCaMPs, SnFRs (we've branched out to neuromodulators and neuropeptides), FPs, viruses, tags, etc. We'll also make whatever you want, but we need $$ to do it. DM or email me, sooner is better. Sorry to be desperate, but we want to keep doing this, and I'm not sure we can."


#neuroscience #GCaMP #RCaMP #SnFR #ProteinEngineering #GECIs

This is a statue located in Berlin, entitled "Politicians Discussing Global Warming."

Signal is a nonprofit. But what does this mean in practice? Today we do something most tech co’s avoid: talk money. What does it cost for Signal to play in a lane dominated by billion $ corporations, while rejecting the surveillance business model?


Work in progress, but beautiful anyway; EPG neurons in the PB of a tropical bee - moving closer towards comparative connectomics. @ERC_Research

Sign-up to present in our symposium (16-17) "Neuropeptide signalling in insects: diverse and pleiotropic actions" @ice2024kyoto_jp in Kyoto, Japan. We have an exciting line-up of speakers. ice2024.org/list-of-accepted-s

Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint shorturl.at/gqrvO where we present the complete neural connectome of an animal circadian clock . 🧵 (1/8) #Drosophila #neuroscience #connectome

The #UK #NHS:

"In 2022, nurses were being paid a fifth less in real terms than they were in 2010. There are more than 110,000 unfilled vacancies within NHS England, in part because better paid, less stressful work is available outside the health service. (I know of a ward that lost its clinical support workers because a coffee chain nearby was offering better pay.)"


New pape from my lab on how the exquisite biomechanical structure of joints, tendons, other doohickeys determine mechanosensory feature selectivity and establish a topographic map of joint angle among proprioceptive sensory neurons in the fly leg. The product of an expansive and fun collaboration across several labs.


A typical European car is parked 92% of the time. It spends 1/5th of its driving time looking for parking. Its 5 seats only move 1.5 people. 86% of its fuel never reaches the wheels, & most of the energy that does, moves the car, not people.

Sound efficient?

HT @circulareconomy

Here is my #introduction. I am a biologist interested in #neuroscience and the #evolution of cells and nervous systems. My research group studies #ciliated marine larvae from a whole-organism perspective, combining behaviour, #connectomics, #imaging, #CRISPR, #modelling and other approaches. We love marine #larvae, their #neurons, #cilia, and #neuropeptides.

Holy _shit_ this paper, and the insight behind it.

You know how every receiver is also a transmitter, _well_: every text predictor is also text compressor, and vice-versa.

You can outperform massive neural networks running millions of parameters, with a novel applications of _gzip_.


Locomotion requires flexible coordination of limbs with many degrees of freedom. How are premotor neural circuits organized to solve this problem? In our new preprint, led by Ellen Lesser and Tony Azevedo, we used connectomics to analyze the wiring logic of motor control networks in the fly.

This fig shows the complete premotor (rows) → motor (columns) connectivity matrices.


We are looking for a postdoc to to help us reveal how neural activity is structured in brainwide patterns to support behavior in mice. The postdoc will study the activity of large populations of neurons in the mouse brain using combined techniques such as #Neuropixels recordings and optogenetics, or rabies tracing and two-photon microscopy. It's an exciting opportunity for research at the interface of computational and experimental #neuroscience. ucl.ac.uk/cortexlab/positions. Deadline is 29 July.

We are hiring! The fly connectomics group is looking for up to 2 new research assistants and up to 2 new postdocs. Come join us in beautiful - we have a great team and exciting new projects in the pipeline!

For details please see these links:

Closing date is July 6th.

Boosts would be very much appreciated!

Bicycles are the future of sustainable living

EVs of all types are already displacing 1.5 million barrels per day of oil usage, equivalent to about 3% of total road fuel demand. Electric bicycles make up 1 million of those barrels. Yet, bicycles get 1% the hype coverage electric cars get. Why? Who advertises in the media? Car companies? Bicycle companies? You can make batteries for over 200 bicycles from one large SUV battery.


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