Philipp Schlegel @uni_matrix@qoto.org

Can we observe how the injured leg of an animal is regenerated?

We have figured out how to do this in the crustacean Parhyale. Over the course of a week, we can record the entire process of leg regeneration at cell-by-cell resolution.

Our latest preprint describes how we do this and what we see:
https://www.biorxiv.org/content/10.1101/2024.09.11.612529v1

More info/links on https://bsky.app/profile/michalis-averof.bsky.social/post/3l3xonnzt6u2n

Enjoying the fruits of my labor now that I finished my 12-legged 'Carpentopod' table project. See
https://decarpentier.nl/carpentopod for project info. (Or come see it live at Maker Days Eindhoven this 13 & 14 Sept.)

Discovery of spiking network model parameters constrained by neural recordings, using simulation-based inference https://www.biorxiv.org/content/10.1101/2024.08.21.608969v2 #neuroscience

The #CampbellSiegert approximation is a method used in #ComputationalNeuroscience to estimate the #firingrate of a #neuron given a certain input. This approximation is particularly useful for analyzing the firing behavior of neurons that follow a leaky #IntegrateAndFire (#LIF) model or similar models under the influence of stochastic input currents. Here is a short #tutorial that introduces the concept in more detail:

🌍 https://www.fabriziomusacchio.com/blog/2024-09-04-campbell_siegert_approximation/

#CompNeuro #neuroscience #PythonTutorial

Our team is looking for an associate news editor with a background or strong interest in neuroscience, cognition and behavior, to write and edit news articles that educate, challenge and inspire our audience of neuroscientists. To apply, please visit: https://simonsfoundation.wd1.myworkdayjobs.com/en-US/simonsfoundationcareers/job/Associate-News-Editor_R0001667

🐣 New feature 🐣

The quick-select tool now works in 3D! Set the prediction depth and segment cells as before, now across multiple sections automatically.

Plus, you can now quick-select with just a click—no more drawing rectangles 🚀 Try it out now !

A great initiative to boost #OpenAccess academic journals. Basically, you pledge not to serve as peer reviewers for venues that do not make publicly available the research that we review. #NoFreeViewNoReview
Join us! Boosts are appreciated.
#academicchatter #academia
https://nofreeviewnoreview.org/

Modern science relies on (open source) software and hardware, but there is currently no incentive for researchers to provide feedback and improvement suggestions for tools that are use in the scientific community despite how valuable these contributions are to the scientific community as a whole. One possible way forward would be to treat "issue creation" and other Git-based activity as an acceptable form of peer review.

This is an issue and idea I’ve been thinking about for a while.I’d love to flesh it out into an actual set of actionable proposals/suggestions, as well as figuring out which (technological) hurdles would need to be overcome, in a opinion-styled paper - could anyone be interested in working on this together with me?

"Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation" Elizabeth Marin et al. 2024
https://elifesciences.org/reviewed-preprints/97766

"This fundamental study provides a near-comprehensive anatomical description and annotation of neurons in a male Drosophila ventral nerve cord, based on large-scale circuit reconstruction from electron microscopy. This connectome resource will be of substantial interest to neuroscientists interested in sensorimotor control, neural development, and analysis of brain connectivity. However, although the evidence is extensive and compelling, the presentation of results in this very large manuscript lacks clarity and concision."

#Drosophila #neuroscience #connectomics #eLifeAssessment

Are you looking to become an assistant professor in Switzerland? This year you have two chances:
1- We've been re-admitted to the @ERC_Research starting grant program, deadline 15 Oct 2024 https://www.admin.ch/gov/en/start/documentation/media-releases.msg-id-101763.html
2- We still have @snsf_ch starting grants, deadline 15 Jan 2025
In both cases, consider @dee_unil as a host institution, we have excellent conditions and a beautiful campus! 😃
#ERC #StartingGrants

How the Tories pushed universities to the brink of disaster.

#UKPol no CW because #HigherEd

https://www.theguardian.com/politics/ng-interactive/2024/jul/02/how-the-tories-pushed-universities-to-the-brink-of-disaster

Presenting: Regexle, a wordle-like game for nerds 🤓

Guess the secret regular expression by testing strings against it!

@piko and I might be two years late with this project, but here we go!

https://regexle.ithea.de

Our preprint "Connectome-driven neural inventory of a complete visual system" (Nern et al., 2024) was published on bioRxiv today https://doi.org/10.1101/2024.04.16.589741. We are looking forward to your feedback on this #Drosophila #neuroscience #prePrint.

In this short thread, I also wanted to highlight a few more resources that we published at the same time. 1/5

Octarine

A new lightweight, WGPU-based 3D viewer for Python.

https://github.com/schlegelp/octarine

You don’t become cooler with age, but you do care progressively less about being cool, which is the only true way of being cool. This is called the Geezer’s Paradox

The Janelia #Unity Toolkit now supports panoramas, back-projected onto a cylindrical screen, updated in real time for a tracked viewpoint within the cylinder. The intended application is #VR for #Neuroscience studies of animals like #Drosophila. The code is a byproduct of another project so it's a bit experimental, but it's fun to watch examples like this one, meant to be displayed with three adjoining projectors. (1/2)

https://github.com/JaneliaSciComp/janelia-unity-toolkit

Update: Elon Musk has announced he’s reinstating the Twitter/X account of far-right conspiracy theorist Alex Jones.