Philipp Schlegel @uni_matrix@qoto.org

From my most fabulous group. Not sure who has migrated over here yet.
They fleas dae braw things wi thir wee heids.

https://www.nature.com/articles/s41586-023-06013-8#peer-review

Kill it with fire.

QT 0xgaut: AI is now indistinguishable from reality.

It's hard to believe, but this ad was AI generated. It's not real.

The future is here.

We have a new preprint! Together with John Pool and colleagues, we have looked at genomes from 200+ year old flies. Many pages, also a lot of tables. Raw reads are on Genbank!
https://www.biorxiv.org/content/10.1101/2023.04.24.538033v1

“Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome”, Pedigo et al. 2023 https://elifesciences.org/articles/83739

“This important work demonstrates a significant asymmetry between the connectivity statistics of the left and right hemispheres of the Drosophila larva brain. The evidence supporting the conclusions is compelling and represents a first step toward the development of statistical tests for comparing pairs of connectomes more generally.”

#connectomics #Drosophila #DrosophilaLarva #brain #neuroscience #eLife

P
http://smbc-comics.com/comic/p-3
#smbc #hivweorks #comics

Stephen Hawking on the NHS https://www.taxresearch.org.uk/Blog/2023/04/19/stephen-hawking-on-the-nhs/

Andreas Schoofs and Mike Pankratz wrote a fantastic Dispatch that embeds our recent paper on insulin production in the wieder literature. Check it out here: https://authors.elsevier.com/a/1gua9_LsQSPrmY

Cajal connectomics training course, "Connectomics from micro- to meso- and macro-scales":
https://cajal-training.org/on-site/connectomics/

Extended deadline: April 17

When: 18 September - 6 October 2023

Where: Bordeaux School of Neuroscience

Taught by Greg Jefferis, Jinny Kim, Nicolas Renier, Casey Schneider-Mizell @csdashm plus outstanding instructors (Philipp Schlegel @uni_matrix , Kathi Eichler, Forrest Collman and many more) and speakers (Genoud, Helmstaedter, Pacureanu, Ueda, Wyart, ...).

#neuroscience #Drosophila #connectomics

I remember when Aaron Swartz was criminally prosecuted for downloading too many academic journal articles, but, sure, it's totally cool to scrape everyone's personal photographs as part of a commercial effort to market discriminatory surveillance tech to police departments.

https://www.businessinsider.com/clearview-scraped-30-billion-images-facebook-police-facial-recogntion-database-2023-4

③ The DABEST proportion plot can replace Fisher’s exact test for the comparison of proportions. It plots the variance of the observed binary counts and the effect-size curve of the difference of proportions. This includes Sankey diagrams for paired proportional data.

CAJAL advanced #neuroscience training program:

“#Connectomics from micro- to meso- and macro-scales”

When: 18 September - 6 October 2023

Where: Bordeaux School of Neuroscience

Applications close soon: 3 April 2023

With Greg Jefferis, Claire Wyart, Moritz Helmstaedter, Casey Scheider-Mizell @csdashm, Chrystel Genoud, Hiroki Ueda, Jinny Kim, Alexandra Pacureanu @APacureanu and more:
https://cajal-training.org/on-site/connectomics/

#introduction I'm a research software developer working in connectomics (neuroscience) in Cambridge, UK.
Likes: ultimate, swordfighting, tabletop RPGs, general nerdery
Dislikes: that conversation adults regularly have about their worst airport experience

Hi Mastodon folks. Twitter is getting quieter so I've clearly lost my previous @scotttishwaddell twitterverse. I'll start posting occasional lab news here too (instead) so please follow if that's of interest. We've lots in the pipeline and I'm missing learning about the other cool science out there that used to flash by my eyes on Twitter. Cheers, Scott. #Introduction #neuroscience #drosophila #dopamine

@kristinmbranson @albertcardona @schoppik @neuroamyo @NicoleCRust @neuralreckoning Isn’t the new eLife model actually one approach to finding a middle ground between hours reading every paper and spot checking journal titles? This thread has good examples of situations where a coarse level of evaluation is needed, and functionally the word “Nature” is often doing roughly the same work as a review summary but with much less information. If done well, summaries could offer a far more specific evaluation of quality and impact than journal title alone while still being able to be read at scale. However, to do that you have to be able to be honestly positive or negative — no one would trust a similar post-acceptance Nature evaluation because they would damn themselves if they ever said “this paper is perfectly fine but not amazing, however the authors have a lot of clout and successfully ignored citing literature they made their paper seem less novel than it was”. eLife has to be willing to associate its name with poorly reviewed papers as well as good ones to avoid this dynamic. If they can show that this new evaluation category adds value, it could spur similar actions.

Science Program Manager @HHMINEWS

https://jobrxiv.org/job/science-program-manager-2/?feed_id=40620

#ScienceJobs #job
Ashburn #UnitedStatesUS #Manager
https://jobrxiv.org/job/science-program-manager-2/?feed_id=40620

We're looking to hire postdocs and an RA! We study how sensory coding and neuronal plasticity rules might be optimised for memory. Postdoc ad: http://bit.ly/LinPostdoc2023 (closes 4 Apr). RA ad: http://bit.ly/LinRA2023 (closes 31 Mar). Please spread the word!

With Jan Löwe and Kasim Sader, we are recruiting two Postdoctoral Scientists to work on #cryoEM specimen preparation:
Closing Date : 10 Apr 2023
More info : https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2095-Postdoctoral-Scientist-Structural-Studies-Dr-Chris-Russo-LMB-2095/en-GB. More info : https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/candidate/so/pm/4/pl/1/opp/2097-Postdoctoral-Scientist-Structural-Studies-Dr-Jan-L%C3%B6we-LMB-2097/en-GB.

Today in dystopian UK news:

NHS — “Junior doctors paid lower hourly rate than workers to get at [popular fastfood restaurant]” https://www.theguardian.com/society/2023/mar/12/junior-doctors-paid-lower-hourly-rate-than-workers-to-get-at-pret

Universities — “One in five students at top universities consider dropping out over cost of living. A quarter are regularly going without food and other essentials” https://www.theguardian.com/education/2023/mar/12/one-in-five-students-at-top-universities-consider-dropping-out-over-cost-of-living

Can the #UK please stop imitating [infamous southern European country]. No matter how well you do it, the sun won’t shine as much.

Today the peer-reviewed version of our preprint is out:

"The #connectome of an insect brain"
https://www.science.org/doi/10.1126/science.add9330

Congrats to co-first authors Michael Winding and Benjamin Pedigo, and to all our lab members and collaborators who made this work possible over the years. A journey that started over 10 years ago–and yet this is but a new beginning. So much more to come.

See my #tootprint on the preprint from back in the Autumn: https://mathstodon.xyz/@albertcardona/109422190525090990

The data is available both as supplements and directly via #CATMAID thanks to hosting by the #VirtualFlyBrain:
https://l1em.catmaid.virtualflybrain.org/?pid=1&zp=108250&yp=82961.59999999999&xp=54210.799999999996&tool=tracingtool&sid0=1&s0=2.4999999999999996&help=true&layout=h(XY,%20%7B%20type:%20%22neuron-search%22,%20id:%20%22neuron-search-1%22,%20options:%20%7B%22annotation-name%22:%20%22papers%22%7D%7D,%200.6)

(The "Winding, Pedigo et al. 2023" annotation listing all included neurons will appear very soon in an upcoming update.)

#neuroscience #connectomics #Drosophila #DrosophilaLarva

I've never been able to comprehend 400ppm or 0.04%. It seems so insignificant and deniers absolutely use that to their advantage.

So I made this:

https://ppm.visuals.earth