@jack@tooter.selfhosting.rocks @zoetropeexplosn@octodon.social @jack@kthejourney.selfhosting.rocks while I do agree that Ketamine seems promising, this is not true. Other antidepressants have been shown to promote neurogenesis: fluoxetine (Prozac, SSRI) (Ohira et al., 2013), venlafaxine (Effexor, SNRI) (Zhang et al., 2015) and even way before: reboxetine (NRI) and tranylcypromine (MAOI) (Malberg et al., 2000). Quite sure most SSRIs and SNRIs do promote neurogenesis.

Another point: neurogenesis is definitely implicated in the antidepressant effect but individual differences (genetics, epigenetics, biochemistry) play a major role in the effectiveness of a drug.. So for instance, fluoxetine works for me, might not work for somebody else. That could be the same for Ketamine. Definitely more research (and funding that research) is mandatory!