wukousen @wukousen@qoto.org

Validation of a biomarker that predicts #Alzheimer's disease in multiple cohorts by assessing astrocyte reactivity (Ast+) in >1,000 people without cognitive impairment

https://www.nature.com/articles/s41591-023-02380-x

I wrote about the Hospital-at-Home movement. https://erictopol.substack.com/p/the-hospital-at-home-movement

Today in generative #AI:
--GPT-4 released and outperforms predecessor
--Med-PaLM2 scores 85% on US medical licensing exam
--I wrote in about this stuff context here
https://erictopol.substack.com/p/multimodal-ai-for-medicine-simplified

When the #AI couldn't pass the radiologist qualifying examination
(with special dispensation)

https://bmj.com/content/379/bmj-2022-072826

在中国医院，最基本的人身自由程度和你的等级成正比，你的等级越高，你的自由程度越高，当规培医生请假时必须在请假单上写“不离沪”否则就不予请假的时候，主任们可以因为各种事由离沪，归根结底，医院需要你这个便宜且好掌控的螺丝钉，于是他们使用一些违法的手段来限制你的自由，且他们不害怕做这样的事情的后果，因为做这样的事收益远远大于成本（规培生人微言轻，且中国医生能选择的岗位极其有限，供需关系极度不平衡，他们没有选择）。而主任们是不可替代的，且拥有更多的就业选择，所以医院给予他们更多的人身自由，以换取这所医院的行业垄断地位。这就是残酷的环境和残酷的现实，所以，在选择非常有限的中国医疗就业环境中，无法通过跳槽来改变自己的生存情况，那么只有一条路，就是去有理有据地抗争，才可能改变自己和同行的处境。

What a tragedy that this good man, who has devoted his life to public service, who has made mistakes and learned from them, and who still expresses a profound understand of America’s public-health problems, should remain a target of vitriol from the worst among us. https://www.nature.com/articles/d41586-022-04432-7

My friend, Fyodor Urnov,
, a pioneer of genome editing, lays out his vision and deep concerns about "word-processer- like control over DNA"
"The invention of CRISPR gene editing gave us remarkable treatment powers, yet no one should do a victory lap."
https://nytimes.com/2022/12/09/opinion/crispr-gene-editing-cures.html?searchResultPosition=1

I wrote about the new anti-obesity drugs—semaglutide (Wegovy) and tirzepatide (Mounjaro)—that represent one of the most important breakthroughs in medicine
https://erictopol.substack.com/p/the-new-obesity-breakthrough-drugs

冬天怎么穿暖和其实最重要的不是羽绒服的选择，而是选择衣物的材质和怎么多层叠穿，也不是鞋本身要多厚，而是叠穿袜子，我生活在体感温度摄氏零下10到20度的冬天已经七年了，分享下经验：
1.最重要的就是叠穿，这是买再厚重质量再好的单一一件羽绒服或者外套都替代不了的。怎么叠穿？最内层：选贴身的合成纤维的速干衣或者羊毛打底，不要选棉的，中层：可以一层或两层，原则是越靠里的越紧外面的越松，单层可以选羊绒羊毛，双层可以再加一层薄羽绒。外层：防风防水的的尼龙材质或者滑雪夹克。最外层：羽绒服或者大衣。分层的原因是层层阻断热量散发，最内层绝对不能穿棉质是第一棉质不容易贴身，第二棉质非常吸水，如果出汗会贴在身上，造成快速和大量的热量流失。下半身裤子同样道理，可以叠三到四层，最外层不用太厚但要防水防风。
2. 如果需要在雪天走要买高筒的，如果之后短的可以买防水徒步绑腿套在外面防止进雪，一旦进雪靴子再暖和都功亏一篑。叠穿袜子最好是两层，里层薄外层厚，羊毛或者合成纤维的都可以，还是不要棉袜！不要棉袜！不要棉袜！
3. 手套，买哆啦A梦的连指款，不买分指的。
4. 戴帽子，要护住耳朵，大衣最好有兜帽可以再戴一层，头冷是最容易让你感到冷的部位，头部保暖做好效果可能超过身上多穿一层内搭。
还有什么问题可以评论问我！

The origin of the...
#OriginOfSpecies

@ziwendong
目前只看到：
看到wikipedia整理出一份「2022年中国大陆反封控抗议」，馬特市森碟整理出一份「中國白紙革命事件簿」
https://www.wikiwand.com/zh/2022%E5%B9%B4%E4%B8%AD%E5%9B%BD%E5%A4%A7%E9%99%86%E5%8F%8D%E5%B0%81%E6%8E%A7%E6%8A%97%E8%AE%AE

https://matters.news/@ryan0601/351265-%E4%B8%AD%E5%9C%8B%E7%99%BD%E7%B4%99%E9%9D%A9%E5%91%BD%E4%BA%8B%E4%BB%B6%E7%B0%BF-%E6%8C%81%E7%BA%8C%E6%9B%B4%E6%96%B0-bafyreihxgzf32sva4etmdgybmidl5ddafwso76bo63d6z4gd542fmh66vi

李和平律师出狱的时候，瘦得几乎脱相，神情也瘦掉了。大概几个月后见到他跟亲友互动的视频。我知道权力不能摧毁他。

寇延丁被指定居所监视居住快一年。她写出来时，知道自己被击垮了。出来之后哪也去不了，只能住在泰山脚下家里。她就每日去行山。后来她出了书，去台湾宣传，然后环岛，了解台湾公民社会的进展，在乡下生活。所有人都劝她留下来。她还是回来了，打算在海南乡下种水稻。FB更新就停留在这里。也已经好几年了。

他们这样活着。甚至没有几个人知道他们。可是这本身就是人的尊严。这激励我。

这也是当权者恐惧的。这样的人存在就是叫当权者恐惧的。

Look who visited! Great to have @Stephanhacker2 at @thecrick to talk about his fantastic work on properly characterizing electrophiles for #DrugDiscovery #chembio!

Just published
@ScienceMagazine

A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, protective in experimental models
https://www.science.org/doi/10.1126/science.abm0271

Vaccine effectiveness vs reinfection, a Denmark nationwide study
The reduction of reinfection after primary vaccination was significant for the Alpha, Delta, and Omicron variant periods, ranging from 60-94%, lasting up to 9 months
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004037 @PLOSMedicine@twitter.com

#TIL
刚刚在《speed reading》这本书里学到了一个震惊我整个人生观的（英文）阅读小技巧：不要看单词文字，而把眼睛聚焦在间隔单词中间的空格上。
我浅试了一下。效果立竿见影，我震惊到下巴脱臼！卧槽，我为什么今天才知道！

大家来试试。记住，不要看单词，把眼睛聚焦在单词中间的点上：
Even • though • you • are • not • looking • at • any • of • the • words • in • this • paragraph • your • eyes • and • mind • are • still • able • to • pick • up • the • text.  • This • happens • because • paying • attention • to • the • spaces • prevents • your • eyes • from • narrowing • their • focus • on • individual • words.

是不是立刻快了很多！！
熟悉了以后，就不用看每两个单词中间的空白了，而是每三个、每四个单词的空白。
比如：

Even though you • are not looking • at individual words • in this paragraph • your eyes and mind • are still able to • pick up the text. • This happens because • paying attention to • spaces between words • prevents your eyes • from narrowing their focus • on individual words.

甚至再往后，可以只看每行中间部分，然后就可以立刻扫描过了。