#gutbrainaxis

Interesting if true: Vagus nerve innervation (controlled by BLA?) to Brunner's glands in the duodenum control the hospitability of the gut to lactobacillus. Ablating the glands renders the gut susceptible to dysbiosis.

An Amygdalar-Vagal-Glandular Circuit Controls the Intestinal Microbiome
Chang et al., preprint at biorxiv 2024
https://doi.org/10.1101/2024.06.02.594027

#neuroscience #vagusnerve #gutbrainaxis

"Taken together, our study demonstrates that members of the Bacteroidota phylum contribute to AD pathogenesis by suppressing microglia phagocytic function, which leads to impaired Aβ clearance and accumulation of amyloid plaques."

Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models
Wasén et al., Nature Communications 2024
https://doi.org/10.1038/s41467-024-47683-w

#neuroscience #gutbacteria #microbiome #microglia #gutbrainaxis

Pleased to finally see this new work out! Lab to lab variability is REAL and sometimes factors that you may not even consider can greatly influence a disease model phenotype. It’s been fun to delve into the #gutbrainaxis and #epilepsy intersection. https://onlinelibrary.wiley.com/doi/10.1111/epi.17946

Mark your calendars: registration & abstract submissions open on Dec 1, 2023 for our #HavingIMPACTT2024 symposium! Head to our website for details, and don't forget to sign up for updates so you don't miss out: https://www.impactt-microbiome.ca/having-impactt-2024-symposium/

#microbiome #microbiota #symposium #conference #research #datascience #health #bioinformatics #biology #multiomics #metabolomics #proteomics #transcriptomics #cancer #gutbrainaxis #immunology #science #

review article from 2022:

Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract
https://doi.org/10.1016/j.sbi.2021.07.009

"The most common allergen in fish, the highly abundant protein β-parvalbumin (PV), forms amyloids that escape gastrointestinal degradation and transit to the blood [34,35]. PV is a small, calcium-binding protein with a helical structure that transforms to amyloids on calcium removal. Because fish is generally considered beneficial toward age-related diseases such as dementia and Alzheimer's disease, we speculated that an explanation would be cross-reactivity of PV amyloids with human amyloidogenic proteins [36∗∗]. Indeed, in vitro experiments showed that PV amyloids readily blocked aS amyloid formation. "

"In addition to fish, other food products contain protein amyloids that are not fully digested in the gut: for example, whey and casein proteins (milk), ovalbumin, lysozyme and ovotransferrin (egg), bovine serum albumin and hemoglobin (blood), and glutelin (wheat) [20]."

The 'Conclusions and outlook' section is very much worth reading, but a bit too long to cut and paste.

#Parkinsons #neurodegeneration #Food #FoodScience #health #GutBrainAxis #GutMicrobiome

@silask Thanks for sharing, this is a) a very cool cool study, and b) scary if true.

If true, then those bacteria have been sitting in plain sight in many brain samples and have never been properly studied (or rejected as surgery artefacts). Should be relatively straightforward to replicate in quite a few labs.

#neuroscience #gutbrainaxis #vagusnerve #neuroinflammation

Very proud of Sameer Alladin, who just published the first preprint of his PhD! It's on proto-#nausea: that slightly funny feeling you get in your #stomach when you experience #disgust!

If you're interested in #Affect, #Emotion, #Interoception, and/or the #gutbrainaxis, you might enjoy it.

Read it here: https://doi.org/10.5281/zenodo.8283453

Registrations are open for our #SummerSchool on Brain, Bacteria and Behaviour.

10 - 14 July in beautiful Nijmegen
learn about #GutBrainAxis
hands-on experience in #GutMicrobiome analyses
early-bird discount until 1 March

https://www.ru.nl/radboudsummerschool/courses/overview-courses-2023/2023-courses/week-4/rss04-16-brain-bacteria-behaviour-understanding/

Can gastrointestinal hormones modulate our reward responses? @cecivez and I ventured into the available data and literature to find that
ghrelin enhances reward responses within the motivational circuit! w/ @nbkroemer

Find more in our pre-print: https://www.biorxiv.org/content/10.1101/2022.11.30.518539v1

#gutbrainaxis #reward #fMRI #ghrelin #GLP1

Microbial-Derived Metabolites Induce Actin Cytoskeletal Rearrangement and Protect Blood-Brain Barrier Function https://www.cell.com/iscience/pdf/S2589-0042(22)01920-4.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004222019204%3Fshowall%3Dtrue

Nice to see the findings from our 2018 paper supported re SCFAs protecting the blood-brain barrier from LPS challenge. https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0439-y

#gutbrainaxis #microbiome

Probiotic Bifidobacteria Mitigate the Deleterious Effects of para-Cresol in a Drosophila melanogaster Toxicity Model https://journals.asm.org/doi/10.1128/msphere.00446-22

- some strains of #bifidobacteria internalized p-cresol from the extracellular environment
- #Probiotic strains to reduce levels of p-cresol sulfate in patients with chronic kidney disease in future?

#microbiome #chronickidneydisease #gutbrainaxis

#introduction

I am enjoying reading lots of different introductions over the last days so I will hop on the train as well and introduce myself!

I am a PhD student at the #neuroscience for motivation, action, and desire lab working with @nbkroemer

I am broadly interested in #decisionmaking and in my PhD I am incorporating a metabolic perspective to understand how the #gutbrainaxis influences neural communication, motivation and effort.

Many psychiatric disorders come along with both motivational and metabolic alterations so the gut-brain perspective might help us to better understand and treat disorders like #depression #anhedonia

Mostly here for all the diverse science

#fmri #cognitiveneuroscience #dopamine #ghrelin

And following the #TwitterMigration Now in the right server Here comes my intro! #neuroscience #neurodon #decisionneuroscience 
Hello everyone! I’m a 4th year PhD candidate focused on decision neuroscience, noninvasive brain stimulation #nibs and the #gutbrainaxis. My research aims at clarifying the neural underpinnings of #risktakingbehavior Check out my work AlineDantas.net and connect!

Very pleased to see this out. Another huge effort from @SimonMcArthur and his research team.

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate is prevented by blockade of the epidermal growth factor receptor https://www.biorxiv.org/content/10.1101/2022.11.12.516113v1

#gutbrainaxis #microbiome #metabolome #chronickidneydisease

#Introductions
I like and care about:
#Microglia
#Microbiota
#Neurodevelopment
#Neuroimmunology
#GutBrainMicrobeAxis
#GutBrainAxis
#SciencePolicy
#RegulatoryScience
#RegulatoryPolicy
#TeaAndBiscotti
I am concerned about:
#COVID
#LongCovid

Hello, and an #introduction.

I use and integrate omics data to understand how the gut microbiota influences mammalian intestinal and systemic health. I'm particularly interested in how microbially produced metabolites interact with host metabolic pathways.

My team is looking at functional and genomic aspects of gut bacteria, especially Klebsiella and Collinsella spp.

I have a soft spot for phages.

#microbiome #NAFLD #cancer #gutbrainaxis