@humanetech Modified organisms where the modification specifically targets reproduction is an exception to the rule.

There've been several variants of this tactic, the ones I'm aware of with mosquitos and flies. Most I'm familiar with release sterilised males --- these will mate with females but produce no offspring. The idea is that there will be much useless faffing around, so to speak.

The article you link is a variant on that: the males are fertile, and will produce viable and fertile male offspring, but female offspring will be nonfertile. That's a reproduction-attack one step removed but also with a multiplier on the attack vector itself (viable but altered male offspring will continue the attack).

There are still risks, but they should be reasonably moderate.

An alternate and riskier strategy would be to introduce some superpredator of the mosquito to the environment. Australia's seen this game played out repeatedly with cane toads, foxes, housecats, and other predators released into the wild.

Other practices, such as the use of ladybird beatles and praying mantises for natural pest reduction, seem largely benign.

@cwebber