#Angiocrine #AlveolarRegeneration

P.aeruginosa Lung injury,#EndothelialCell KO of Sphk1, S1P-generating enzyme->
Excess Sftpc-hi AT2
AT1 loss & airspace enlargement

S1P/S1PR2#YAP nucleation->AT2-to-AT1 differentiation

Dr. Yuru Liu lab Cell Reports 2020
https://www.sciencedirect.com/science/article/pii/S2211124720308093