Linda V Sinclair @Lvsinclair@qoto.org
Immunologist, working with Cantrell Lab. Interested in LOTS - focused on nutrient and metabolic control of the immune system. Twitter handle @LindaVSinclair
Engineering amino acid metabolism in CAR-T cells #Slc7a5 #Slc7a11
Very interesting approach. We are now regularly seeing metabolic engineering strategies to improve cellular immunotherapies.
#immunometabolism
Neutrophils are a real metabolic enigma!! They are packed full of glycogen particles and now it appears that beta oxidation is crucial in getting them to the site of infection. Maybe they save the glycogen as fuel for when they arrive? 🤷♂️🧐🤓
#teamMassSpec I've officially joined mastodon. My focus is #proteomics focussed to #immunology particularly working on #tcells and #neutrophils
RT @dundeeuni
The acidity of tumours impairs the effectiveness of anti-cancer therapies, according to a study led by Dr Ignacio Moraga, @UoDLifeSciences. The findings could lead to a new generation of immunotherapy treatments.
More 👉 https://buff.ly/3VPspcy
We recently developed a new single cell assay (QUAS-R) to measure glutamine uptake through Slc1a5.
Check it out on BioRxiv https://www.biorxiv.org/content/10.1101/2022.09.29.510040v1. Fun collaboration with Linda Sinclair and Sander van Kasteren
Immunologist, working with Cantrell Lab. Interested in LOTS - focused on nutrient and metabolic control of the immune system. Twitter handle @LindaVSinclair
