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You can't stop evolution

A paper published in Nature yesterday reports on how an engineered minimal cell contends with the forces of evolution.

Open access paper available here: nature.com/articles/s41586-023

Dr Veera M. Rajagopal on Twitter has a good summary on the development of the minimal genome (the barest minimum of a bacterial genome required for life), which led to the engineering of the minimal cell.

If you're on Twitter, it's available here: twitter.com/doctorveera/status

According to the Nature paper: even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

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