How human-derived brain organoids are built differently from brain organoids derived of genetically-close relatives: A multi-scale hypothesis https://www.biorxiv.org/content/10.1101/2023.05.25.542171v1?med=mas
"Incidentally, Hi-C maps of human versus chimpanzee stems demonstrate differences [84]. Such differences in spatial organization of the genome can potentially translate into differences in gene expression dynamics, such as ZEB2. Moreover, the spatial organization of chromatin can be modified by a change in the
shape of a nucleus, which is often due to a change in the
shape of the cell with cell nuclear shape often mimicking cell shape [85, 86]."
@biorxivpreprint
"What do we mean by a mechanical means of regulating
transcription? ... Chromatin is spatially
& temporarily organized within the cell nucleus. While
a difference in genetic sequence between, say, a chimpanzee and a human, is rather small - approximately
about 1.2% - perhaps even this rather small difference in genetic sequence translates into potentially larger
differences in spatial organization of the genome inside
a cell nucleus."