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"We show that memories of mitotic duration are integrated by a p53-based mitotic stopwatch pathway to exert tight control over proliferation. The stopwatch halts proliferation of the products of a single significantly extended mitosis or of successive modestly extended mitoses. Time in mitosis is monitored via mitotic kinase-regulated assembly of stopwatch complexes that are transmitted to daughter cells."
@cyrilpedia I've not had a deep read of this 😍 pre-print from Oegama/Desai team but I was struck @StearnsLab about parallels of 'stopwatches' for your work with Emily on Hh, #cilia for how long in #CellCycle determining steps at subsequent #mitosis. This idea of counting time over multiple cycles is very cool. https://www.cell.com/current-biology/pdfExtended/S0960-9822(20)30643-6