Rapid, direct, and sequence-specific identification of RNA viruses in various crop plants using CRISPR/Cas13a biorxiv.org/content/10.1101/20

Multiparameter Quantitative Analyses of Diagnostic Cells in Brain Tissues from Tuberous Sclerosis Complex biorxiv.org/content/10.1101/20

"Uma vez que o pós-doutoramento é um passo necessário, na maior parte das áreas, para se conseguir uma posição de professor, esta queda da atratividade estará provavelmente ligada à dificuldade em atingir uma posição permanente e à precariedade que continua a existir e de que falei no último artigo. Muitos investigadores têm por isso mudado para empresas de biotecnologia e farmacêuticas, que oferecem estabilidade profissional e um ordenado bastante superior ou mesmo optado por sair da ciência."

publico.pt/2024/02/20/ciencia/

Help support other future research leaders in genomics and data science by contributing now to the James P. Taylor Foundation for Open Science. We sponsor conference participation and arrange mentorship opportunities for outstanding graduate students. Help the future! jxtxfoundation.org/donate/

The paper by David Klatzmann was especially interesting to discuss because of his seemingly simple deduction of the receptor based on his previous results on cell tropism, science.org/doi/10.1126/scienc, and on an old retrovirus technique called "receptor interference" which lead to straightforward experiments to test his idea. Its a nice model of a simple hypothesis that turned out to be true, although the additional complications of virus entry were not understood until later.

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This week in our monthly "Classic Papers in HIV" journal club we discussed two papers published 40 years ago that identified CD4 as the receptor for HIV. doi.org/10.1038/312767a0 and doi.org/10.1038/312763a0 . #Virology #HIV #lablife #science #ClassicPapers #ThrowbackThursday

Just came across this study in Nature Comms suggesting that a mouth germ, Porphyromonas gingivalis, might play a role in making gut problems like colitis worse. Interesting, right? But here’s the thing - their oral gavage model for the mice involved an enormous amount of this bacteria! like 10^9 CFUs! Oof, that's not your everyday exposure, even on your worst dental hygiene day. #microbiome [1/2]

sciencemastodon.com/@bykriscam

"We thought we knew how Voyager would end. The power would gradually, inevitably, run down. The instruments would shut off, one by one. The signal would get fainter. Eventually either the last instrument would fail for lack of power, or the signal would be lost.

We didn’t expect that it would go mad."
(via The Browser)

crookedtimber.org/2024/02/19/d

'Dramatists in Shakespeare’s time had worked in much the same way. In my brief glimpses of writers’ rooms, I saw the potential. One day, working on a fictional series that went nowhere, our team included an Italian woman who had been flown in for her expertise in writing female characters. Every writer has weaknesses and blind spots. A good writers’ room has fewer.'

ft.com/content/db9682f9-e0c0-4

"
The UK has lost more than three-quarters of its great skuas on surveyed sites since bird flu struck, according to the first report quantifying the impact of H5N1 on seabird populations.

The deaths have happened over two years, since the outbreak of H5N1 in 2021. The UK is internationally important for seabirds, home to most of the world’s 16,000 pairs of nesting great skuas"

theguardian.com/environment/20

"What might come as a big surprise to those of us deeply embedded in academic culture is that what we have achieved doesn’t matter so much as what we are capable of doing. That tall stack of publications might have zero value outside academia, but all of the talents that we racked up in the process of producing those papers can be highly valuable."

scienceforeveryone.substack.co

“Estamos desamparados”, qualifica uma bolseira de 41 anos ouvida pelo PÚBLICO. Pediu a prorrogação da bolsa em Setembro de 2023 e não recebe desde Novembro. Gastou boa parte das poupanças a colmatar as despesas que tem e já teve de renegociar o crédito à habitação para acomodar a ausência de salário. “Não tenho outra fonte de rendimento”, diz.'

publico.pt/2024/02/14/ciencia/

"With this perspective, our intent is to provide some orientation—and some sense of calm—while navigating the diversity of CRISPR tools, recognizing what needs to be done to make them better and tackling the technical, regulatory and other challenges. Inspired by Douglas Adams’ classic scientific-fiction comedy novel The Hitchhiker’s Guide to the Galaxy (1979), this article is our attempt to provide a brief, and hopefully informative, tour with this hitchhiker’s guide to the universe of -based editing tools in bacteria."
Krink et al @emboreports
embopress.org/doi/full/10.1038

'Uma profissional de saúde que trabalha na organização Médicos Sem Fronteiras estava ao lado de um local atingido por um bombardeamento israelita. “Escrevi os nomes dos meus filhos e da minha família nos seus pulsos e nas suas pernas, para que possamos ser identificados se formos bombardeados”, contou em mensagens de texto ao resto da equipa na Palestina, mensagens que a organização divulgou."

publico.pt/2024/02/14/mundo/no

#gaza #palestine #historic #picture #peace

@palestine

#Jaffa #beach, Palestine 1921. Long gone times....citizens of all ethnicities and religions once lived peacefully. Picture by Dr. Mustafa Elmasri, Gaza.

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