Thiago Carvalho @cyrilpedia@qoto.org

Clinical studies suggest that patients treated with the new class of weight- loss drugs, known as GLP-1s, lose muscle at far faster rates than people losing weight from diet or exercise, exposing them to health problems, said George Yancopoulos, who also serves as Regeneron’s chief scientific officer.
https://www.ft.com/content/094cbf1f-c5a8-4bb3-a43c-988bd8e2dea9

'Springer Nature shares gained 8.2 per cent to close at €24.24 in Frankfurt, having priced the stock in the IPO around the middle of its targeted range at €22.50. The rise valued Springer, which sold €600mn of shares as part of the deal, at €4.8bn.'

https://www.ft.com/content/6905d256-787b-433b-9272-fd1100b05fbc

'In this work, we developed a mRNA–LNP vaccine targeting C. difficile toxins & virulence factors. This multivalent vaccine elicited robust and long-lived systemic & mucosal antigen-specific humoral and cellular immune responses across animal models, independent of changes to the intestinal microbiota.'
#Immunology

https://www.science.org/doi/10.1126/science.adn4955

'In a panic, I asked a graduate student in my lab for help. We defined a goal for the paper, and I carefully wrote an outline. But when I asked him for feedback, I soon found the paper covered in red marks. Not again.

Before I could retreat in defeat, though, the graduate student explained that red didn’t mean I was a bad writer. Writing isn’t a one-and-done thing. It requires revising your work, often several times. Suddenly it occurred to me, “Hadn’t I done the same thing when I was searching for an efficient inductor design?”'

https://www.science.org/content/article/i-hated-writing-until-i-learned-there-s-science-it

'O teste aprovado pela OMS – o Alinity mMPXV fabricado pelos laboratórios Abbott Molecular – é um teste PCR em tempo real que pode detectar o ADN do vírus, tanto da variante 1 como da variante 2, a partir de esfregaços de lesões cutâneas humana.'

https://www.publico.pt/2024/10/04/ciencia/noticia/oms-luz-verde-teste-diagnosticar-mpox-2106576

'To his credit, Jones does not back away. His narrative of Henry’s life is a chronicle of coldhearted decisions, of sieges and massacres, of close friends executed for their real or perceived disloyalty, of heretics burned at the stake, of a damaged soul incapable of gentleness or love. This was Shakespeare’s problem as well, and it is an artistic miracle that the playwright managed to acknowledge much of what was truly awful about Henry without alienating the audience from him. Instead, his play brings the audience ever closer to what was transpiring inside the lonely young king.'
https://www.nytimes.com/2024/10/04/books/review/henry-v-dan-jones.html

'Think about it: fakery is what AI image-generating systems do; it's their entire raison d'être. You give them prompts so that they will whip up something plausible, something that looks like what you wanted. So whip me up a good looking Western blot, or maybe just a selection of good-looking bands that I can use in my Frankensteined Westerns where they won't appear duplicated!'

https://www.science.org/content/blog-post/helpful-robot-assistants-will-fake-it-you