"We probed the B cell repertoire from peripheral blood of mothers with primary and secondary ZIKV infections and established 9 ZIKV-binding B lymphoblastoid cell lines (B-LCL). One of them produced an IgM antibody, DH1017.IgM, in its native pentameric conformation. DH1017.IgM was somatically mutated, did not cross-react with other flaviviruses, displayed ultrapotent ZIKV neutralization that depended on its isotype and protected mice from viremia more efficiently than the respective IgG upon lethal ZIKV challenge."

#Immunology #ZIKA #virology
#Cell

https://www.sciencedirect.com/science/article/pii/S0092867422013691?dgcid=coauthor