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"Should this framework be correct, the extensive ongoing efforts devoted to targeting amygdala circuits and rodent behaviors such as freezing and avoidance are unlikely to provide a direct route to treatments for human fear and anxiety disorders. These lines of research can help, but not without recognizing the centrality of subjective experience."
@NicoleCRust & Joseph E.LeDoux, 'The tricky business of defining brain functions' @TrendsNeuro
https://www.sciencedirect.com/science/article/pii/S0166223622002132?dgcid=author
@cyrilpedia @TrendsNeuro Thank you for amplifying this - it's a really important point, I think. Joe LeDoux @amygdaloid has been saying this for a while now. I fear that way too few have been listening.
In my mind, we understand so little about brain function, that the neural correlates of nearly anything are valuable. Work on the amygdala is unquestionably that. But taking that next step toward translational impact - how will the amygdala fit in? That's the discussion that needs to be had.