"We conclude that, although several ways that induce extended lifespan through mitochondrial dysfunction require a functional mitochondrial unfolded protein response, there is no clear indication that activation of the mitochondrial unfolded protein response is sufficient to extend lifespan, despite the fact that the mitochondrial unfolded protein response impacts almost every aspect of mitochondrial function."
@cyrilpedia I know zero, zilch, nada about #mitochondria, but I did give my very best effort at understanding this. Five is at least one too many times for the word to appear in any comprehensible sentence...🤯😉
@awford The makes sense - the excerpt is from a paper aimed at specialised readers (biochemists, cell biologists etc).
In general terms, mitochondria are cellular power stations and they are thought to be important in ageing because burning all that fuel. much like burning fuel in other contexts, has a lot of toxic byproducts.
@cyrilpedia and now I know a little more, thanks!
@awford If you want to know a bit more, this is a good video for a broader audience (but one that is still rigorous and accurate). Mitochondria are essentially domesticated bacteria that our cells use to make energy
@cyrilpedia ie, cooperative evolution?
@awford Protection and a stable supply of nutrients are two possibilities
@cyrilpedia Thanks again for letting me sidetrack your post. Got the video in my playlist now 👍
@awford I hope you like it, thanks for the comments
@cyrilpedia Appreciate the generalized terminology. So what do mitochondria get in return? I always like to understand a relationship in it's inverse. ♾️