Your reminder that Barbara McClintock was awesome for more reasons that just discovering mobile genetic elements:

"Barbara McClintock was at that time correlating phenotypic changes in maize plants with cytogenetic alterations in the chromosomes. In crosses involving ring and normal linear chromosomes, chromosome breakage would occur and she could follow the fate of the broken ends. These studies led McClintock to propose that a natural chromosome must differ from broken chromosomes in possessing a structure that provides stability to the end"

From Carol Greider's 1996 @AnnualReviews article.

https://www.annualreviews.org/doi/10.1146/annurev.bi.65.070196.002005